A role for peripheral blood fibrocytes in Lyme disease?

D. J. Grab, M. Salim, J. Chesney, R. Bucala, H. N. Lanners

Research output: Contribution to journalArticlepeer-review

Abstract

It is proposed that peripheral blood fibrocytes will be a new and important player in the pathogenesis of Lyme disease. Peripheral blood fibrocytes are a circulating leukocyte subpopulation that: (a) express collagen; (b) are an abundant source of cytokines, chemoattractants and growth factors; and (c) are able to recruit and activate naive T-cells and memory T-cells. We predict that peripheral blood fibrocytes will represent a new and important antigen-presenting cell which will play an important role in directing the immune response from the pathogenic Th1 to the protective Th2 response cell in Borrelia infections.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalMedical Hypotheses
Volume59
Issue number1
DOIs
StatePublished - Jul 2002

ASJC Scopus subject areas

  • Developmental Biology
  • Medicine(all)
  • Drug Discovery

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