A role for immune complexes in enhanced respiratory syncytial virus disease

Fernando P. Polack, Michael N. Teng, Peter L. Collins, Gregory A. Prince, Marcus Exner, Heinz Regele, Dario D. Lirman, Richard T Rabold, Scott J. Hoffman, Christopher L. Karp, Steven R. Kleeberger, Marsha Wills-Karp, Ruth A. Karron

Research output: Contribution to journalArticlepeer-review

Abstract

Respiratory syncytial virus (RSV) is the leading cause of bronchiolitis and viral pneumonia in infants and young children. Administration of a formalin inactivated vaccine against RSV to children in the 1960s resulted in increased morbidity and mortality in vaccine recipients who subsequently contracted RSV. This incident precluded development of subunit RSV vaccines for infants for over 30 years, because the mechanism of illness was never clarified. An RSV vaccine for infants is still not available. Here, we demonstrate that enhanced RSV disease is mediated by immune complexes and abrogated in complement component C3 and B cell-deficient mice but not in controls. Further, we show correlation with the enhanced disease observed in children by providing evidence of complement activation in postmortem lung sections from children with enhanced RSV disease.

Original languageEnglish (US)
Pages (from-to)859-865
Number of pages7
JournalJournal of Experimental Medicine
Volume196
Issue number6
DOIs
StatePublished - Sep 16 2002

Keywords

  • Airway hyperresponsiveness
  • Compliment
  • Enhanced disease
  • Immune complexes
  • Respiratory syncytial virus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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