A role for hydrogen bonding in DNA recognition by the non-classical CCHHC type zinc finger, NZF-1

Angelique N. Besold; Deborah L. Amick; Sarah L.J. Michel

doi:10.1039/c4mb00246f

A role for hydrogen bonding in DNA recognition by the non-classical CCHHC type zinc finger, NZF-1

Angelique N. Besold, Deborah L. Amick, Sarah L.J. Michel

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The non-classical zinc finger protein, Neural Zinc Finger Factor-1, contains six Cys₂His₂Cys domains. All three cysteines and the second histidine directly bind Zn(ii). Using a combination of mutagenesis, metal coordination and DNA binding studies, we report that the first histidine is involved in a functionally important hydrogen bonding interaction. This journal is

Original language	English (US)
Pages (from-to)	1753-1756
Number of pages	4
Journal	Molecular BioSystems
Volume	10
Issue number	7
DOIs	https://doi.org/10.1039/c4mb00246f
State	Published - Jul 2014
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Molecular Biology

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10.1039/c4mb00246f

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title = "A role for hydrogen bonding in DNA recognition by the non-classical CCHHC type zinc finger, NZF-1",

abstract = "The non-classical zinc finger protein, Neural Zinc Finger Factor-1, contains six Cys2His2Cys domains. All three cysteines and the second histidine directly bind Zn(ii). Using a combination of mutagenesis, metal coordination and DNA binding studies, we report that the first histidine is involved in a functionally important hydrogen bonding interaction. This journal is",

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AU - Amick, Deborah L.

AU - Michel, Sarah L.J.

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AB - The non-classical zinc finger protein, Neural Zinc Finger Factor-1, contains six Cys2His2Cys domains. All three cysteines and the second histidine directly bind Zn(ii). Using a combination of mutagenesis, metal coordination and DNA binding studies, we report that the first histidine is involved in a functionally important hydrogen bonding interaction. This journal is

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A role for hydrogen bonding in DNA recognition by the non-classical CCHHC type zinc finger, NZF-1

Abstract

ASJC Scopus subject areas

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