A role for hydrogen bonding in DNA recognition by the non-classical CCHHC type zinc finger, NZF-1

Angelique N. Besold, Deborah L. Amick, Sarah L.J. Michel

Research output: Contribution to journalArticlepeer-review

Abstract

The non-classical zinc finger protein, Neural Zinc Finger Factor-1, contains six Cys2His2Cys domains. All three cysteines and the second histidine directly bind Zn(ii). Using a combination of mutagenesis, metal coordination and DNA binding studies, we report that the first histidine is involved in a functionally important hydrogen bonding interaction. This journal is

Original languageEnglish (US)
Pages (from-to)1753-1756
Number of pages4
JournalMolecular BioSystems
Volume10
Issue number7
DOIs
StatePublished - Jul 2014
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Biology

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