A rodent cell line permissive for entry and reverse transcription of human immunodeficiency virus type 1 has a pre-integration block to productive infection

J. H M Simon, G. A. Schockmel, Peter B Illei, W. James

Research output: Contribution to journalArticle

Abstract

Replication of human immunodeficiency virus type 1 (HIV-1) is restricted to CD4-expressing primate cells. This tropism may be due partly to the absence from non-primate cells of a species-specific factor which has an accessory role to CD4 during virus penetration. In this study we describe a rat B lymphocyte cell line in which there is efficient CD4-dependent entry of HIV-1. However, this cell line has a block to productive infection of HIV-1 at a stage between reverse transcription and integration. Our results demonstrate that the putative accessory factor for HIV-1 penetration is not restricted to primate cells and that there is a novel, uncharacterized cell-virus interaction at a stage between penetration and integration.

Original languageEnglish (US)
Pages (from-to)2615-2623
Number of pages9
JournalJournal of General Virology
Volume75
Issue number10
StatePublished - 1994
Externally publishedYes

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Reverse Transcription
HIV-1
Rodentia
Cell Line
Infection
Primates
Viruses
Tropism
Cell Communication
B-Lymphocytes

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

A rodent cell line permissive for entry and reverse transcription of human immunodeficiency virus type 1 has a pre-integration block to productive infection. / Simon, J. H M; Schockmel, G. A.; Illei, Peter B; James, W.

In: Journal of General Virology, Vol. 75, No. 10, 1994, p. 2615-2623.

Research output: Contribution to journalArticle

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