A robust spike and wave algorithm for detecting seizures in a genetic absence seizure model

Petros Xanthopoulos, Chang Chia Liu, Jicong Zhang, Eric R. Miller, S. P. Nair, Basim M. Uthman, Kevin Kelly, Panos M. Pardalos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Animal Models are used extensively in basic epilepsy research. In many studies, there is a need to accurately score and quantify all epileptic spike and wave discharges (SWDs) as captured by electroencephalographic (EEG) recordings. Manual scoring of long term EEG recordings is a time-consuming and tedious task that requires inordinate amount of time of laboratory personnel and an experienced electroencephalographer. In this paper, we adapt a SWD detection algorithm, originally proposed by the authors for absence (petit mal) seizure detection in humans, to detect SWDs appearing in EEG recordings of Fischer 334 rats. The algorithm is robust with respect to the threshold parameters. Results are compared to manual scoring and the effect of different threshold parameters is discussed.

Original languageEnglish (US)
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Pages2184-2187
Number of pages4
DOIs
StatePublished - 2009
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

Fingerprint

Absence Epilepsy
Seizures
Laboratory Personnel
Inbred F344 Rats
Epilepsy
Animal Models
Rats
Animals
Research
Personnel

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

Cite this

Xanthopoulos, P., Liu, C. C., Zhang, J., Miller, E. R., Nair, S. P., Uthman, B. M., ... Pardalos, P. M. (2009). A robust spike and wave algorithm for detecting seizures in a genetic absence seizure model. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 2184-2187). [5334941] https://doi.org/10.1109/IEMBS.2009.5334941

A robust spike and wave algorithm for detecting seizures in a genetic absence seizure model. / Xanthopoulos, Petros; Liu, Chang Chia; Zhang, Jicong; Miller, Eric R.; Nair, S. P.; Uthman, Basim M.; Kelly, Kevin; Pardalos, Panos M.

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 2184-2187 5334941.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Xanthopoulos, P, Liu, CC, Zhang, J, Miller, ER, Nair, SP, Uthman, BM, Kelly, K & Pardalos, PM 2009, A robust spike and wave algorithm for detecting seizures in a genetic absence seizure model. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5334941, pp. 2184-2187, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5334941
Xanthopoulos P, Liu CC, Zhang J, Miller ER, Nair SP, Uthman BM et al. A robust spike and wave algorithm for detecting seizures in a genetic absence seizure model. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 2184-2187. 5334941 https://doi.org/10.1109/IEMBS.2009.5334941
Xanthopoulos, Petros ; Liu, Chang Chia ; Zhang, Jicong ; Miller, Eric R. ; Nair, S. P. ; Uthman, Basim M. ; Kelly, Kevin ; Pardalos, Panos M. / A robust spike and wave algorithm for detecting seizures in a genetic absence seizure model. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. pp. 2184-2187
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