A roadmap to advance delirium research: Recommendations from the NIDUS Scientific Think Tank

NIDUS Writing Group

doi:10.1002/alz.12076

A roadmap to advance delirium research: Recommendations from the NIDUS Scientific Think Tank

NIDUS Writing Group

School of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Delirium is an acute disorder of attention and cognition. It occurs across the life span, yet it is particularly common among older adults, and is closely linked with underlying neurocognitive disorders. Evidence is mounting that intervening on delirium may represent an important opportunity for delaying the onset or progression of dementia. To accelerate the current understanding of delirium, the Network for Investigation of Delirium: Unifying Scientists (NIDUS) held a conference “Advancing Delirium Research: A Scientific Think Tank” in June 2019. This White Paper encompasses the major knowledge and research gaps identified at the conference: advancing delirium definition and measurement, understanding delirium pathophysiology, and prevention and treatment of delirium. A roadmap of research priorities is proposed to advance the field in a systematic, interdisciplinary, and coordinated fashion. A call is made for an international consortium and biobank targeted to delirium, as well as a public health campaign to advance the field.

Original language	English (US)
Pages (from-to)	726-733
Number of pages	8
Journal	Alzheimer's and Dementia
Volume	16
Issue number	5
DOIs	https://doi.org/10.1002/alz.12076
State	Published - May 1 2020

Keywords

biomarkers
definition
delirium
dementia
diagnosis
measurement
pathophysiology
prevention
public health campaign
treatment

ASJC Scopus subject areas

Epidemiology
Health Policy
Developmental Neuroscience
Clinical Neurology
Geriatrics and Gerontology
Cellular and Molecular Neuroscience
Psychiatry and Mental health

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10.1002/alz.12076

Cite this

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title = "A roadmap to advance delirium research: Recommendations from the NIDUS Scientific Think Tank",

abstract = "Delirium is an acute disorder of attention and cognition. It occurs across the life span, yet it is particularly common among older adults, and is closely linked with underlying neurocognitive disorders. Evidence is mounting that intervening on delirium may represent an important opportunity for delaying the onset or progression of dementia. To accelerate the current understanding of delirium, the Network for Investigation of Delirium: Unifying Scientists (NIDUS) held a conference “Advancing Delirium Research: A Scientific Think Tank” in June 2019. This White Paper encompasses the major knowledge and research gaps identified at the conference: advancing delirium definition and measurement, understanding delirium pathophysiology, and prevention and treatment of delirium. A roadmap of research priorities is proposed to advance the field in a systematic, interdisciplinary, and coordinated fashion. A call is made for an international consortium and biobank targeted to delirium, as well as a public health campaign to advance the field.",

keywords = "biomarkers, definition, delirium, dementia, diagnosis, measurement, pathophysiology, prevention, public health campaign, treatment",

author = "{NIDUS Writing Group} and Oh, {Esther S.} and Oluwaseun Akeju and Avidan, {Michael S.} and Colm Cunningham and Hayden, {Kathleen M.} and Jones, {Richard N.} and Khachaturian, {Ara S.} and Khan, {Babar A.} and Marcantonio, {Edward R.} and Needham, {Dale M.} and Neufeld, {Karin J.} and Louise Rose and Jessica Spence and Zo{\"e} Tieges and Phillip Vlisides and Inouye, {Sharon K.}",

note = "Funding Information: This work was funded by grant no. R24AG054259 from the National Institute on Aging, Grant no. R24AG054259, which created the Network for Investigation of Delirium: Unifying Scientists (NIDUS). Publisher Copyright: {\textcopyright} 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association",

year = "2020",

month = may,

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doi = "10.1002/alz.12076",

language = "English (US)",

volume = "16",

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journal = "Alzheimer's and Dementia",

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AU - NIDUS Writing Group

AU - Oh, Esther S.

AU - Akeju, Oluwaseun

AU - Avidan, Michael S.

AU - Cunningham, Colm

AU - Hayden, Kathleen M.

AU - Jones, Richard N.

AU - Khachaturian, Ara S.

AU - Khan, Babar A.

AU - Marcantonio, Edward R.

AU - Needham, Dale M.

AU - Neufeld, Karin J.

AU - Rose, Louise

AU - Spence, Jessica

AU - Tieges, Zoë

AU - Vlisides, Phillip

AU - Inouye, Sharon K.

N1 - Funding Information: This work was funded by grant no. R24AG054259 from the National Institute on Aging, Grant no. R24AG054259, which created the Network for Investigation of Delirium: Unifying Scientists (NIDUS). Publisher Copyright: © 2020 The Authors. Alzheimer's & Dementia published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association

PY - 2020/5/1

Y1 - 2020/5/1

N2 - Delirium is an acute disorder of attention and cognition. It occurs across the life span, yet it is particularly common among older adults, and is closely linked with underlying neurocognitive disorders. Evidence is mounting that intervening on delirium may represent an important opportunity for delaying the onset or progression of dementia. To accelerate the current understanding of delirium, the Network for Investigation of Delirium: Unifying Scientists (NIDUS) held a conference “Advancing Delirium Research: A Scientific Think Tank” in June 2019. This White Paper encompasses the major knowledge and research gaps identified at the conference: advancing delirium definition and measurement, understanding delirium pathophysiology, and prevention and treatment of delirium. A roadmap of research priorities is proposed to advance the field in a systematic, interdisciplinary, and coordinated fashion. A call is made for an international consortium and biobank targeted to delirium, as well as a public health campaign to advance the field.

AB - Delirium is an acute disorder of attention and cognition. It occurs across the life span, yet it is particularly common among older adults, and is closely linked with underlying neurocognitive disorders. Evidence is mounting that intervening on delirium may represent an important opportunity for delaying the onset or progression of dementia. To accelerate the current understanding of delirium, the Network for Investigation of Delirium: Unifying Scientists (NIDUS) held a conference “Advancing Delirium Research: A Scientific Think Tank” in June 2019. This White Paper encompasses the major knowledge and research gaps identified at the conference: advancing delirium definition and measurement, understanding delirium pathophysiology, and prevention and treatment of delirium. A roadmap of research priorities is proposed to advance the field in a systematic, interdisciplinary, and coordinated fashion. A call is made for an international consortium and biobank targeted to delirium, as well as a public health campaign to advance the field.

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KW - definition

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KW - diagnosis

KW - measurement

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KW - prevention

KW - public health campaign

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A roadmap to advance delirium research: Recommendations from the NIDUS Scientific Think Tank

Abstract

Keywords

ASJC Scopus subject areas

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