A review on the management of epilepsy associated with hypothalamic hamartomas

James L. Frazier; C. Rory Goodwin; Edward S. Ahn; George I. Jallo

doi:10.1007/s00381-008-0798-y

A review on the management of epilepsy associated with hypothalamic hamartomas

James L. Frazier, C. Rory Goodwin, Edward S. Ahn, George I. Jallo

School of Medicine

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Introduction: Hypothalamic hamartomas are rare congenital malformations located in the region of the tuber cinereum and third ventricle. Patients may be asymptomatic, but the usual presentation is gelastic seizures, precocious puberty, and/or developmental delay. Clinical presentation: Without surgical intervention, the gelastic seizures, which are typically present in childhood, may progress to other seizure types, including generalized epilepsy, and are generally refractory to antiepileptic drugs. Summary: This review will discuss the clinical and electrophysiologic aspects of these lesions, as well as treatment options, including surgery, endoscopy, and radiosurgery.

Original language	English (US)
Pages (from-to)	423-432
Number of pages	10
Journal	Child's Nervous System
Volume	25
Issue number	4
DOIs	https://doi.org/10.1007/s00381-008-0798-y
State	Published - Apr 1 2009

Keywords

Epilepsy
Gelastic seizure
Hypothalamic hamartoma
Radiosurgery
Surgery

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Clinical Neurology

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10.1007/s00381-008-0798-y

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title = "A review on the management of epilepsy associated with hypothalamic hamartomas",

abstract = "Introduction: Hypothalamic hamartomas are rare congenital malformations located in the region of the tuber cinereum and third ventricle. Patients may be asymptomatic, but the usual presentation is gelastic seizures, precocious puberty, and/or developmental delay. Clinical presentation: Without surgical intervention, the gelastic seizures, which are typically present in childhood, may progress to other seizure types, including generalized epilepsy, and are generally refractory to antiepileptic drugs. Summary: This review will discuss the clinical and electrophysiologic aspects of these lesions, as well as treatment options, including surgery, endoscopy, and radiosurgery.",

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AU - Frazier, James L.

AU - Goodwin, C. Rory

AU - Ahn, Edward S.

AU - Jallo, George I.

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N2 - Introduction: Hypothalamic hamartomas are rare congenital malformations located in the region of the tuber cinereum and third ventricle. Patients may be asymptomatic, but the usual presentation is gelastic seizures, precocious puberty, and/or developmental delay. Clinical presentation: Without surgical intervention, the gelastic seizures, which are typically present in childhood, may progress to other seizure types, including generalized epilepsy, and are generally refractory to antiepileptic drugs. Summary: This review will discuss the clinical and electrophysiologic aspects of these lesions, as well as treatment options, including surgery, endoscopy, and radiosurgery.

AB - Introduction: Hypothalamic hamartomas are rare congenital malformations located in the region of the tuber cinereum and third ventricle. Patients may be asymptomatic, but the usual presentation is gelastic seizures, precocious puberty, and/or developmental delay. Clinical presentation: Without surgical intervention, the gelastic seizures, which are typically present in childhood, may progress to other seizure types, including generalized epilepsy, and are generally refractory to antiepileptic drugs. Summary: This review will discuss the clinical and electrophysiologic aspects of these lesions, as well as treatment options, including surgery, endoscopy, and radiosurgery.

KW - Epilepsy

KW - Gelastic seizure

KW - Hypothalamic hamartoma

KW - Radiosurgery

KW - Surgery

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A review on the management of epilepsy associated with hypothalamic hamartomas

Abstract

Keywords

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