A review of the efficacy of mitomycin C in glaucoma filtration surgery

Ahmed Al Habash, Leyla Ali Aljasim, Ohoud Owaidhah, Deepak P. Edward

Research output: Contribution to journalArticle

Abstract

The success of trabeculectomy, which is considered the gold standard in the surgical treatment of glaucoma, depends on the wound healing response. The introduction of antiproliferative agents such as mitomycin C (MMC) has increased the success rates of trabeculectomy. However, complications due to these agents can be challenging to manage. Hence, it is important to determine the most efficacious dose and duration of exposure. Multiple studies suggest that many factors, including but not limited to MMC preparation, different concentrations, different exposure times, and method of application may affect success rate, and these factors were reviewed in this article. We concluded that lower concentrations of MMC that are prepared and applied in a standardized fashion, such as that using the Mitosol® kit (for 2–3 minutes) during trabeculectomy, could potentially provide trabeculectomy success rates similar to that reported with off-label preparations, and that such a treatment regime could result in in lower complication rates than higher doses of MMC.

Original languageEnglish (US)
Pages (from-to)1945-1951
Number of pages7
JournalClinical Ophthalmology
Volume9
DOIs
StatePublished - Oct 20 2015

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Keywords

  • Filtering surgery
  • Mitomycin C
  • Mitosol
  • Outcomes
  • Trabeculectomy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Al Habash, A., Aljasim, L. A., Owaidhah, O., & Edward, D. P. (2015). A review of the efficacy of mitomycin C in glaucoma filtration surgery. Clinical Ophthalmology, 9, 1945-1951. https://doi.org/10.2147/OPTH.S80111