A review of induced pluripotent stem cell, direct conversion by trans-differentiation, direct reprogramming and oligodendrocyte differentiation

Ankshita Prasad, Janani Manivannan, Daniel T.B. Loong, Soo M. Chua, Payam M. Gharibani, Angelo H. All

Research output: Contribution to journalReview article

Abstract

Rapid progress in the field of stem cell therapy and cellular reprogramming provides convincing evidence of its feasibility in treating a wide range of pathologies through autologous cell replacement therapy. This review article describes in detail on three widely used approaches of somatic cell reprogramming: induced pluripotent stem cells, direct conversion and direct reprogramming, in the context of demyelination in the CNS. The potential limitations of each reprogramming technique are reviewed along with their distinct molecular approach to reprogramming. This is followed by an analysis on the scopes and challenges of its translational applications in deriving oligodendrocyte progenitor cells and oligodendrocytes for cell replacement treatment of demyelinating conditions in the CNS.

Original languageEnglish (US)
Pages (from-to)181-191
Number of pages11
JournalRegenerative Medicine
Volume11
Issue number2
DOIs
StatePublished - Mar 2016

Keywords

  • direct conversion
  • direct reprogramming
  • iPSC reprogramming
  • oligodendrocytes
  • transdifferentiation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology

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