Abstract
Rapid progress in the field of stem cell therapy and cellular reprogramming provides convincing evidence of its feasibility in treating a wide range of pathologies through autologous cell replacement therapy. This review article describes in detail on three widely used approaches of somatic cell reprogramming: induced pluripotent stem cells, direct conversion and direct reprogramming, in the context of demyelination in the CNS. The potential limitations of each reprogramming technique are reviewed along with their distinct molecular approach to reprogramming. This is followed by an analysis on the scopes and challenges of its translational applications in deriving oligodendrocyte progenitor cells and oligodendrocytes for cell replacement treatment of demyelinating conditions in the CNS.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 181-191 |
| Number of pages | 11 |
| Journal | Regenerative Medicine |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 1 2016 |
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Keywords
- direct conversion
- direct reprogramming
- iPSC reprogramming
- oligodendrocytes
- transdifferentiation
ASJC Scopus subject areas
- Biomedical Engineering
- Embryology
Cite this
A review of induced pluripotent stem cell, direct conversion by trans-differentiation, direct reprogramming and oligodendrocyte differentiation. / Prasad, Ankshita; Manivannan, Janani; Loong, Daniel T B; Chua, Soo M.; Mohammadgharibani, Payam; All, Angelo Homayoun.
In: Regenerative Medicine, Vol. 11, No. 2, 01.03.2016, p. 181-191.Research output: Contribution to journal › Article
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TY - JOUR
T1 - A review of induced pluripotent stem cell, direct conversion by trans-differentiation, direct reprogramming and oligodendrocyte differentiation
AU - Prasad, Ankshita
AU - Manivannan, Janani
AU - Loong, Daniel T B
AU - Chua, Soo M.
AU - Mohammadgharibani, Payam
AU - All, Angelo Homayoun
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Rapid progress in the field of stem cell therapy and cellular reprogramming provides convincing evidence of its feasibility in treating a wide range of pathologies through autologous cell replacement therapy. This review article describes in detail on three widely used approaches of somatic cell reprogramming: induced pluripotent stem cells, direct conversion and direct reprogramming, in the context of demyelination in the CNS. The potential limitations of each reprogramming technique are reviewed along with their distinct molecular approach to reprogramming. This is followed by an analysis on the scopes and challenges of its translational applications in deriving oligodendrocyte progenitor cells and oligodendrocytes for cell replacement treatment of demyelinating conditions in the CNS.
AB - Rapid progress in the field of stem cell therapy and cellular reprogramming provides convincing evidence of its feasibility in treating a wide range of pathologies through autologous cell replacement therapy. This review article describes in detail on three widely used approaches of somatic cell reprogramming: induced pluripotent stem cells, direct conversion and direct reprogramming, in the context of demyelination in the CNS. The potential limitations of each reprogramming technique are reviewed along with their distinct molecular approach to reprogramming. This is followed by an analysis on the scopes and challenges of its translational applications in deriving oligodendrocyte progenitor cells and oligodendrocytes for cell replacement treatment of demyelinating conditions in the CNS.
KW - direct conversion
KW - direct reprogramming
KW - iPSC reprogramming
KW - oligodendrocytes
KW - transdifferentiation
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UR - http://www.scopus.com/inward/citedby.url?scp=84962331254&partnerID=8YFLogxK
U2 - 10.2217/rme.16.5
DO - 10.2217/rme.16.5
M3 - Article
C2 - 26857809
AN - SCOPUS:84962331254
VL - 11
SP - 181
EP - 191
JO - Regenerative Medicine
JF - Regenerative Medicine
SN - 1746-0751
IS - 2
ER -