A Review of DNA Methylation and microRNA Expression in Recurrent Pediatric Acute Leukemia

Victoria Hale, Gregory A. Hale, Patrick A Brown, Ernest Amankwah

Research output: Contribution to journalArticle

Abstract

Acute leukemia is the most common childhood cancer diagnosis and leading cause of cancer-related death among children and adolescents. Despite substantial improvements in the survival rate of childhood acute leukemia, approximately 20-40% of the patients who undergo treatment develop relapse, with a dismal one third of these patients surviving in the long term. Epigenetics plays an important role in the progression of cancer, and existing evidence suggests a role in childhood acute leukemia relapse. A better understanding of the epigenetic mechanisms in recurrent acute leukemia could potentially lead to novel therapeutic regimens to prevent or treat disease recurrences. In this review, we summarize existing evidence on two of the most studied epigenetic mechanisms, DNA methylation and microRNA expression, in recurrent pediatric acute leukemia.

Original languageEnglish (US)
JournalOncology
DOIs
Publication statusAccepted/In press - Nov 2 2016

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Keywords

  • Epigenetics
  • Methylation
  • microRNA
  • Pediatric leukemia
  • Recurrence

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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