TY - JOUR
T1 - A retrospective study on the association of gastrointestinal symptoms in children with low lactase activity and low activity of other disaccharidases
AU - Wasuwanich, Paul
AU - Choudry, Hassan
AU - Ingviya, Thammasin
AU - Scheimann, Ann O.
AU - Auyeung, Karla J.
AU - Karwowski, Christine
AU - Billet, Susan
AU - Nichols, Buford L.
AU - Karnsakul, Wikrom
N1 - Publisher Copyright:
© 2020 The Author(s).
PY - 2020/10/9
Y1 - 2020/10/9
N2 - Background: Disaccharides such as lactose and sucrose are sugars commonly found in human diet. They are broken down by mucosal disaccharidases in the duodenum. Previous small studies found no associations between gastrointestinal (GI) symptoms and combined low disaccharidase activity. We aim to explore the associations of low activity of disaccharidase and combinations of low activity of different disaccharidases with general GI symptom presentations in a large cohort of pediatric patients. Methods: We examined a cohort (0-21 yrs.) who have undergone esophagogastroduodenoscopy and received disaccharidase activity assay from duodenal biopsy in the time period 2010 to 2012. Disaccharidase assays tested for activity of lactase, sucrase, maltase, and palatinase. GI symptoms were grouped into four categories, abdominal pain, diarrhea, weight loss, and gastroesophageal reflux. Results: Of the 347 subjects, we found an association between low lactase activity and abdominal pain (OR = 1.78; 95% CI = 1.07-2.97; p < 0.05). Subjects with a lactase/sucrase ratio < 0.2 were found to be associated with abdominal pain (OR = 2.25; 95% CI = 1.25-4.04; p < 0.05), Subjects with low pandisaccharidase may be correlated with abdominal pain and have a unique frequency of GI symptoms due to low frequency of diarrhea and weight loss, but they were not statistically significant. Conclusions: Low activities of certain disaccharidase combinations may be associated with GI symptoms in subjects; a prospective study may be needed to investigate further.
AB - Background: Disaccharides such as lactose and sucrose are sugars commonly found in human diet. They are broken down by mucosal disaccharidases in the duodenum. Previous small studies found no associations between gastrointestinal (GI) symptoms and combined low disaccharidase activity. We aim to explore the associations of low activity of disaccharidase and combinations of low activity of different disaccharidases with general GI symptom presentations in a large cohort of pediatric patients. Methods: We examined a cohort (0-21 yrs.) who have undergone esophagogastroduodenoscopy and received disaccharidase activity assay from duodenal biopsy in the time period 2010 to 2012. Disaccharidase assays tested for activity of lactase, sucrase, maltase, and palatinase. GI symptoms were grouped into four categories, abdominal pain, diarrhea, weight loss, and gastroesophageal reflux. Results: Of the 347 subjects, we found an association between low lactase activity and abdominal pain (OR = 1.78; 95% CI = 1.07-2.97; p < 0.05). Subjects with a lactase/sucrase ratio < 0.2 were found to be associated with abdominal pain (OR = 2.25; 95% CI = 1.25-4.04; p < 0.05), Subjects with low pandisaccharidase may be correlated with abdominal pain and have a unique frequency of GI symptoms due to low frequency of diarrhea and weight loss, but they were not statistically significant. Conclusions: Low activities of certain disaccharidase combinations may be associated with GI symptoms in subjects; a prospective study may be needed to investigate further.
KW - Abdominal pain
KW - Disaccharidases deficiency
KW - Lactase-Phlorizin hydrolase
KW - Maltase-Glucoamylase
KW - Sucrase-Isomaltase complex
UR - http://www.scopus.com/inward/record.url?scp=85092477093&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85092477093&partnerID=8YFLogxK
U2 - 10.1186/s12876-020-01443-4
DO - 10.1186/s12876-020-01443-4
M3 - Article
C2 - 33036568
AN - SCOPUS:85092477093
SN - 1471-230X
VL - 20
JO - BMC Gastroenterology
JF - BMC Gastroenterology
IS - 1
M1 - 331
ER -