TY - JOUR
T1 - A Retrospective Observational Study of Anesthetic Induction Dosing Practices in Female Elderly Surgical Patients
T2 - Are We Overdosing Older Patients?
AU - Akhtar, Shamsuddin
AU - Heng, Joseph
AU - Dai, Feng
AU - Schonberger, Robert B.
AU - Burg, Mathew M.
N1 - Publisher Copyright:
© 2016, Springer International Publishing Switzerland.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Background/Objectives: Despite guidelines suggesting a 25–50 % reduction in induction doses of intravenous anesthetic agents in the elderly (≥65 years), we hypothesized that practitioners were not sufficiently correcting drug administration for age, contributing to an increased incidence of hypotension in older patients undergoing general anesthesia. Study Design: We conducted a retrospective, observational study in a tertiary-care academic hospital. The study included 768 female patients undergoing gynecologic surgeries who received propofol-based induction of general anesthesia. Main Outcome Measures: Weight-adjusted anesthetic induction dosing, age-associated differences in dosing by ASA-PS (American Society of Anesthesiology—Physical Status), and hemodynamic outcomes between younger (18–64 years, n = 537) and older (≥65 years, n = 231) female patients were analyzed. Results: Older patients received lower doses of propofol and midazolam than younger patients (propofol: 2.037 ± 0.783 vs 2.322 ± 0.834 mg/kg, p < 0.001; midazolam: 0.013 ± 0.014 vs 0.023 ± 0.042 mg/kg, p < 0.001). However, practitioners still consistently exceeded the FDA recommended dose (1–1.5 mg/kg) of propofol for elderly patients. There was no significant difference in the doses of fentanyl administered between the two age groups (1.343 ± 0.744 vs 1.363 ± 0.763 μg/kg, p = 0.744), and doses of fentanyl in older patients exceeded the recommended dose (0.5–1.0 μg/kg). Corresponding to observed overdosing of induction agents, older patients experienced larger decreases in post-induction blood pressure and were more likely to receive vasopressor therapy. Conclusions: Anesthetic induction doses of fentanyl and propofol were not sufficiently corrected in older patients in accordance with recommendations. Significantly greater frequency of post-induction hypotension occurred amongst older patients. Quality improvement efforts may lead to improved outcomes in this vulnerable population.
AB - Background/Objectives: Despite guidelines suggesting a 25–50 % reduction in induction doses of intravenous anesthetic agents in the elderly (≥65 years), we hypothesized that practitioners were not sufficiently correcting drug administration for age, contributing to an increased incidence of hypotension in older patients undergoing general anesthesia. Study Design: We conducted a retrospective, observational study in a tertiary-care academic hospital. The study included 768 female patients undergoing gynecologic surgeries who received propofol-based induction of general anesthesia. Main Outcome Measures: Weight-adjusted anesthetic induction dosing, age-associated differences in dosing by ASA-PS (American Society of Anesthesiology—Physical Status), and hemodynamic outcomes between younger (18–64 years, n = 537) and older (≥65 years, n = 231) female patients were analyzed. Results: Older patients received lower doses of propofol and midazolam than younger patients (propofol: 2.037 ± 0.783 vs 2.322 ± 0.834 mg/kg, p < 0.001; midazolam: 0.013 ± 0.014 vs 0.023 ± 0.042 mg/kg, p < 0.001). However, practitioners still consistently exceeded the FDA recommended dose (1–1.5 mg/kg) of propofol for elderly patients. There was no significant difference in the doses of fentanyl administered between the two age groups (1.343 ± 0.744 vs 1.363 ± 0.763 μg/kg, p = 0.744), and doses of fentanyl in older patients exceeded the recommended dose (0.5–1.0 μg/kg). Corresponding to observed overdosing of induction agents, older patients experienced larger decreases in post-induction blood pressure and were more likely to receive vasopressor therapy. Conclusions: Anesthetic induction doses of fentanyl and propofol were not sufficiently corrected in older patients in accordance with recommendations. Significantly greater frequency of post-induction hypotension occurred amongst older patients. Quality improvement efforts may lead to improved outcomes in this vulnerable population.
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U2 - 10.1007/s40266-016-0394-x
DO - 10.1007/s40266-016-0394-x
M3 - Article
C2 - 27581549
AN - SCOPUS:84984820167
SN - 1170-229X
VL - 33
SP - 737
EP - 746
JO - Drugs and Aging
JF - Drugs and Aging
IS - 10
ER -