TY - JOUR
T1 - A retrospective case-control study of the relationship between the gut microbiota, enteropathy, and child growth
AU - Perin, Jamie
AU - Burrowes, Vanessa
AU - Almeida, Mathieu
AU - Ahmed, Shahnawaz
AU - Haque, Rashidul
AU - Parvin, Tahmina
AU - Biswas, Shwapon
AU - Azmi, Ishrat J.
AU - Bhuyian, Sazzadul Islam
AU - Talukder, Kaisar A.
AU - Faruque, Abu G.
AU - Stine, O. C.
AU - George, Christine Marie
N1 - Publisher Copyright:
© 2020 American Society of Tropical Medicine and Hygiene. All rights reserved.
PY - 2020/7
Y1 - 2020/7
N2 - The microbial communities residing in the child gut are thought to play an important role in child growth, although the relationship is not well understood. We examined a cohort of young children from Mirzapur, Bangladesh, prospectively over 18 months. Four fecal markers of environmental enteropathy (EE) (high levels of alpha-1-antitrypsin, calprotectin, myeloperoxidase, and neopterin) were examined and anthropometric measures obtained from a cohort of 68 children. The 16S rRNA gene of bacterial DNA was sequenced from stool samples and used to estimate amplicon sequence variants (ASVs). We age-matched children with poor growth to children with normal growth within 1 month and compared the change in abundance and diversity of ASVs over time. Elevated EE markers and poor linear growth in children were associated with changes in microbial communities in the gut. There were increased amounts of Escherichia/Shigella and Proteobacteria and decreased amounts of Prevotella associated with poorly growing children consistent with the mounting evidence supporting the relationship between intestinal inflammation, child growth, and changes in gut microbiota composition. Future research is needed to investigate this association among young children in low- A nd middle-income countries.
AB - The microbial communities residing in the child gut are thought to play an important role in child growth, although the relationship is not well understood. We examined a cohort of young children from Mirzapur, Bangladesh, prospectively over 18 months. Four fecal markers of environmental enteropathy (EE) (high levels of alpha-1-antitrypsin, calprotectin, myeloperoxidase, and neopterin) were examined and anthropometric measures obtained from a cohort of 68 children. The 16S rRNA gene of bacterial DNA was sequenced from stool samples and used to estimate amplicon sequence variants (ASVs). We age-matched children with poor growth to children with normal growth within 1 month and compared the change in abundance and diversity of ASVs over time. Elevated EE markers and poor linear growth in children were associated with changes in microbial communities in the gut. There were increased amounts of Escherichia/Shigella and Proteobacteria and decreased amounts of Prevotella associated with poorly growing children consistent with the mounting evidence supporting the relationship between intestinal inflammation, child growth, and changes in gut microbiota composition. Future research is needed to investigate this association among young children in low- A nd middle-income countries.
UR - http://www.scopus.com/inward/record.url?scp=85088200918&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85088200918&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.19-0761
DO - 10.4269/ajtmh.19-0761
M3 - Article
C2 - 32431271
AN - SCOPUS:85088200918
SN - 0002-9637
VL - 103
SP - 520
EP - 527
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 1
ER -