A retrospective analysis of diseases associated with indeterminate HIV Western blot patterns

J. J. Drabick; V. L. Horning; J. L. Lennox; P. E. Coyne; C. N. Oster; R. D. Knight; T. A. Dillard; S. A. Fuller; J. J. Damato; D. S. Burke

doi:10.1093/milmed/156.2.93

A retrospective analysis of diseases associated with indeterminate HIV Western blot patterns

J. J. Drabick, V. L. Horning, J. L. Lennox, P. E. Coyne, C. N. Oster, R. D. Knight, T. A. Dillard, S. A. Fuller, J. J. Damato, D. S. Burke

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Some individuals possess antibodies which react to HIV-1 Western blot proteins in patterns not diagnostic for HIV infection. A retrospective chart review of patients exhibiting such indeterminate HIV Western blots was performed in comparison to a control cohort of sex- and age-matched individuals from the same population of HIV-negative blots to determine if such blots were associated with any specific disease states. Twenty such patients with 25 indeterminate blots among them were found in a total population of 816 (2.5%). GAG-only (core) Western blots comprised the majority 84% (21/25). An indeterminate blot was statistically associated with Hashimoto's thyroiditis (p < 0.01) and non-Hodgkin's lymphoma (p < 0.05). Kikuchi's disease and malignant histiocytosis were associated but the numbers were too small to reach statistical significance. The possibility that these diseases are caused by novel retroviruses, cross-reactive with HIV-1, is discussed in lieu of these findings.

Original language	English (US)
Pages (from-to)	93-94
Number of pages	2
Journal	Military medicine
Volume	156
Issue number	2
DOIs	https://doi.org/10.1093/milmed/156.2.93
State	Published - 1991
Externally published	Yes

ASJC Scopus subject areas

General Medicine

Access to Document

10.1093/milmed/156.2.93

Cite this

@article{d71edb5ea6794e43abcf644810e129a5,

title = "A retrospective analysis of diseases associated with indeterminate HIV Western blot patterns",

abstract = "Some individuals possess antibodies which react to HIV-1 Western blot proteins in patterns not diagnostic for HIV infection. A retrospective chart review of patients exhibiting such indeterminate HIV Western blots was performed in comparison to a control cohort of sex- and age-matched individuals from the same population of HIV-negative blots to determine if such blots were associated with any specific disease states. Twenty such patients with 25 indeterminate blots among them were found in a total population of 816 (2.5%). GAG-only (core) Western blots comprised the majority 84% (21/25). An indeterminate blot was statistically associated with Hashimoto's thyroiditis (p < 0.01) and non-Hodgkin's lymphoma (p < 0.05). Kikuchi's disease and malignant histiocytosis were associated but the numbers were too small to reach statistical significance. The possibility that these diseases are caused by novel retroviruses, cross-reactive with HIV-1, is discussed in lieu of these findings.",

author = "Drabick, {J. J.} and Horning, {V. L.} and Lennox, {J. L.} and Coyne, {P. E.} and Oster, {C. N.} and Knight, {R. D.} and Dillard, {T. A.} and Fuller, {S. A.} and Damato, {J. J.} and Burke, {D. S.}",

year = "1991",

doi = "10.1093/milmed/156.2.93",

language = "English (US)",

volume = "156",

pages = "93--94",

journal = "Military medicine",

issn = "0026-4075",

publisher = "Association of Military Surgeons of the US",

number = "2",

}

TY - JOUR

T1 - A retrospective analysis of diseases associated with indeterminate HIV Western blot patterns

AU - Drabick, J. J.

AU - Horning, V. L.

AU - Lennox, J. L.

AU - Coyne, P. E.

AU - Oster, C. N.

AU - Knight, R. D.

AU - Dillard, T. A.

AU - Fuller, S. A.

AU - Damato, J. J.

AU - Burke, D. S.

PY - 1991

Y1 - 1991

N2 - Some individuals possess antibodies which react to HIV-1 Western blot proteins in patterns not diagnostic for HIV infection. A retrospective chart review of patients exhibiting such indeterminate HIV Western blots was performed in comparison to a control cohort of sex- and age-matched individuals from the same population of HIV-negative blots to determine if such blots were associated with any specific disease states. Twenty such patients with 25 indeterminate blots among them were found in a total population of 816 (2.5%). GAG-only (core) Western blots comprised the majority 84% (21/25). An indeterminate blot was statistically associated with Hashimoto's thyroiditis (p < 0.01) and non-Hodgkin's lymphoma (p < 0.05). Kikuchi's disease and malignant histiocytosis were associated but the numbers were too small to reach statistical significance. The possibility that these diseases are caused by novel retroviruses, cross-reactive with HIV-1, is discussed in lieu of these findings.

AB - Some individuals possess antibodies which react to HIV-1 Western blot proteins in patterns not diagnostic for HIV infection. A retrospective chart review of patients exhibiting such indeterminate HIV Western blots was performed in comparison to a control cohort of sex- and age-matched individuals from the same population of HIV-negative blots to determine if such blots were associated with any specific disease states. Twenty such patients with 25 indeterminate blots among them were found in a total population of 816 (2.5%). GAG-only (core) Western blots comprised the majority 84% (21/25). An indeterminate blot was statistically associated with Hashimoto's thyroiditis (p < 0.01) and non-Hodgkin's lymphoma (p < 0.05). Kikuchi's disease and malignant histiocytosis were associated but the numbers were too small to reach statistical significance. The possibility that these diseases are caused by novel retroviruses, cross-reactive with HIV-1, is discussed in lieu of these findings.

UR - http://www.scopus.com/inward/record.url?scp=0026082141&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026082141&partnerID=8YFLogxK

U2 - 10.1093/milmed/156.2.93

DO - 10.1093/milmed/156.2.93

M3 - Article

C2 - 1900597

AN - SCOPUS:0026082141

SN - 0026-4075

VL - 156

SP - 93

EP - 94

JO - Military medicine

JF - Military medicine

IS - 2

ER -

A retrospective analysis of diseases associated with indeterminate HIV Western blot patterns

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this