A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity

Karina Pino-Lagos, Yanxia Guo, Chrysothemis Brown, Matthew P. Alexander, Raúl Elgueta, Kathryn A. Bennett, Victor De Vries, Elizabeth Nowak, Rune Blomhoff, Shanthini Sockanathan, Roshantha A. Chandraratna, Ethan Dmitrovsky, Randolph J. Noelle

Research output: Contribution to journalArticle

Abstract

It is known that vitamin A and its metabolite, retinoic acid (RA), are essential for host defense. However, the mechanisms for how RA controls inflammation are incompletely understood. The findings presented in this study show that RA signaling occurs concurrent with the development of inflammation. In models of vaccination and allogeneic graft rejection, whole body imaging reveals that RA signaling is temporally and spatially restricted to the site of inflammation. Conditional ablation of RA signaling in T cells significantly interferes with CD4+ T cell effector function, migration, and polarity. These findings provide a new perspective of the role of RA as a mediator directly controlling CD4+ T cell differentiation and immunity.

Original languageEnglish (US)
Pages (from-to)1767-1775
Number of pages9
JournalJournal of Experimental Medicine
Volume208
Issue number9
DOIs
StatePublished - Aug 29 2011

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Tretinoin
Cellular Immunity
T-Lymphocytes
Inflammation
Whole Body Imaging
Graft Rejection
Vitamin A
Cell Differentiation
Immunity
Vaccination

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Pino-Lagos, K., Guo, Y., Brown, C., Alexander, M. P., Elgueta, R., Bennett, K. A., ... Noelle, R. J. (2011). A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity. Journal of Experimental Medicine, 208(9), 1767-1775. https://doi.org/10.1084/jem.20102358

A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity. / Pino-Lagos, Karina; Guo, Yanxia; Brown, Chrysothemis; Alexander, Matthew P.; Elgueta, Raúl; Bennett, Kathryn A.; De Vries, Victor; Nowak, Elizabeth; Blomhoff, Rune; Sockanathan, Shanthini; Chandraratna, Roshantha A.; Dmitrovsky, Ethan; Noelle, Randolph J.

In: Journal of Experimental Medicine, Vol. 208, No. 9, 29.08.2011, p. 1767-1775.

Research output: Contribution to journalArticle

Pino-Lagos, K, Guo, Y, Brown, C, Alexander, MP, Elgueta, R, Bennett, KA, De Vries, V, Nowak, E, Blomhoff, R, Sockanathan, S, Chandraratna, RA, Dmitrovsky, E & Noelle, RJ 2011, 'A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity', Journal of Experimental Medicine, vol. 208, no. 9, pp. 1767-1775. https://doi.org/10.1084/jem.20102358
Pino-Lagos K, Guo Y, Brown C, Alexander MP, Elgueta R, Bennett KA et al. A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity. Journal of Experimental Medicine. 2011 Aug 29;208(9):1767-1775. https://doi.org/10.1084/jem.20102358
Pino-Lagos, Karina ; Guo, Yanxia ; Brown, Chrysothemis ; Alexander, Matthew P. ; Elgueta, Raúl ; Bennett, Kathryn A. ; De Vries, Victor ; Nowak, Elizabeth ; Blomhoff, Rune ; Sockanathan, Shanthini ; Chandraratna, Roshantha A. ; Dmitrovsky, Ethan ; Noelle, Randolph J. / A retinoic acid-dependent checkpoint in the development of CD4+ T cell-mediated immunity. In: Journal of Experimental Medicine. 2011 ; Vol. 208, No. 9. pp. 1767-1775.
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