A retina-derived stimulator(s) of retinal pigment epithelial cell and astrocyte proliferation

Peter A. Campochiaro, Bert M. Glaser

Research output: Contribution to journalArticlepeer-review

Abstract

Retinal detachments are frequently accompanied by retinal pigment epithelial cell and glial cell proliferation. This may be important in the pathogenesis of proliferative vitreoretinopathy and may also play a role in the failure of some eyes to regain visual function despite anatomically successful retinal reattachment surgery. In this study, we demonstrate that a retina-derived substance or substances stimulates the proliferation of retinal pigment epithelial cells (250% above control) and astrocytes (150% above control) in vitro. The stimulation of proliferation occurs in the absence of serum, but is accentuated by serum. There is some degree of target-cell specificity as there is no stimulation of smooth-muscle-cell proliferation. Morphologic changes induced in the proliferating cell types as well as preliminary characterization suggest that one or more of the previously described eye-derived growth factors may be involved.

Original languageEnglish (US)
Pages (from-to)449-457
Number of pages9
JournalExperimental eye research
Volume43
Issue number3
DOIs
StatePublished - Sep 1986

Keywords

  • PVR
  • RPE
  • cell proliferation
  • glial cells
  • retinal detachments

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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