A reservoir model for repeated CSF access in the rabbit

Michael A. Samphilipo; Samuel J. Hassenbusch; Louise B. Grochow; Frank L. Starr; James H. Anderson

doi:10.1016/0165-0270(87)90088-4

A reservoir model for repeated CSF access in the rabbit

Michael A. Samphilipo, Samuel J. Hassenbusch, Louise B. Grochow, Frank L. Starr, James H. Anderson

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A simple, reliable and inexpensive subcutaneously implanted reservoir-catheter system method was developed for repeated sterile access to the rabbit brain ventricular system. The system provides an avenue for the repeated intrathecal administration of drugs and for the withdrawal of cerebrospinal fluid (CSF). Reservoirs were subcutaneously implanted under the scalp and connected to tubing inserted into the cisterna magna or the lateral ventricle. The systems successfully functioned in 38 of 41 animals (12 with cisternal magna catheters and 29 with lateral ventricle catheters), for up to 12 weeks following implantation. Patency of the systems were documented with X-rays and radiopaque injected contrast medium.

Original language	English (US)
Pages (from-to)	47-52
Number of pages	6
Journal	Journal of Neuroscience Methods
Volume	22
Issue number	1
DOIs	https://doi.org/10.1016/0165-0270(87)90088-4
State	Published - Nov 1987
Externally published	Yes

Keywords

Cerebrospinal fluid
Intrathecal
Rabbit
Reservoir

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/0165-0270(87)90088-4

Cite this

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title = "A reservoir model for repeated CSF access in the rabbit",

abstract = "A simple, reliable and inexpensive subcutaneously implanted reservoir-catheter system method was developed for repeated sterile access to the rabbit brain ventricular system. The system provides an avenue for the repeated intrathecal administration of drugs and for the withdrawal of cerebrospinal fluid (CSF). Reservoirs were subcutaneously implanted under the scalp and connected to tubing inserted into the cisterna magna or the lateral ventricle. The systems successfully functioned in 38 of 41 animals (12 with cisternal magna catheters and 29 with lateral ventricle catheters), for up to 12 weeks following implantation. Patency of the systems were documented with X-rays and radiopaque injected contrast medium.",

keywords = "Cerebrospinal fluid, Intrathecal, Rabbit, Reservoir",

author = "Samphilipo, {Michael A.} and Hassenbusch, {Samuel J.} and Grochow, {Louise B.} and Starr, {Frank L.} and Anderson, {James H.}",

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T1 - A reservoir model for repeated CSF access in the rabbit

AU - Samphilipo, Michael A.

AU - Hassenbusch, Samuel J.

AU - Grochow, Louise B.

AU - Starr, Frank L.

AU - Anderson, James H.

N1 - Funding Information: ~s work has been supported by NIH Grant CA37870-03

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AB - A simple, reliable and inexpensive subcutaneously implanted reservoir-catheter system method was developed for repeated sterile access to the rabbit brain ventricular system. The system provides an avenue for the repeated intrathecal administration of drugs and for the withdrawal of cerebrospinal fluid (CSF). Reservoirs were subcutaneously implanted under the scalp and connected to tubing inserted into the cisterna magna or the lateral ventricle. The systems successfully functioned in 38 of 41 animals (12 with cisternal magna catheters and 29 with lateral ventricle catheters), for up to 12 weeks following implantation. Patency of the systems were documented with X-rays and radiopaque injected contrast medium.

KW - Cerebrospinal fluid

KW - Intrathecal

KW - Rabbit

KW - Reservoir

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A reservoir model for repeated CSF access in the rabbit

Abstract

Keywords

ASJC Scopus subject areas

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