[A resected case of hilar cholangiocarcinoma treated with neoadjuvant chemoradiation therapy].

Kensuke Yamada, Kazuhiko Sakamoto, Takao Tamesa, Hiroto Matsui, Yoshitaro Shindo, Yukio Tokumitsu, Noriaki Hashimoto, Michihisa Iida, Yoshinari Maeda, Yoshihiro Tokuhisa, Nobuaki Suzuki, Kiyoshi Yoshimura, Tomio Ueno, Masataro Takahashi, Keiko Shibuya, Tomoko Kondo, Masaaki Oka

Research output: Chapter in Book/Report/Conference proceedingChapter


The patient was a 69-year-old woman with elevated levels of hepatobiliary enzymes. An abdominal computed tomography (CT) scan revealed an enhanced mass in the liver hilum with dilatation of the intrahepatic bile duct. We diagnosed hilar cholangiocarcinoma and administered neoadjuvant chemoradiation therapy because of the possibility of tumor cells remaining at the surgical margins. Radical surgery was performed and pathological examination showed the tumor to be Grade 2b according to the Oboshi-Shimosato classification. Although postoperative bile leakage and intra-abdominal abscess were observed, the patient was discharged on day 82 after surgery. The patient is still alive without recurrence at 17 months after the surgery. Neoadjuvant chemoradiation therapy has the potential to obtain a negative surgical margin in patients with hilar cholangiocarcinoma, which is likely to be positive for cancer cells at the surgical margin in preoperative diagnosis.

Original languageEnglish (US)
Title of host publicationGan to kagaku ryoho. Cancer & chemotherapy
Number of pages3
StatePublished - 2013
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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