A reporter transgene based on a human keratin 6 gene promoter is specifically expressed in the periderm of mouse embryos

Stacy Mazzalupo, Pierre A. Coulombe

Research output: Contribution to journalArticle

Abstract

We report the developmental regulation of a lacZ reporter transgene fused to the promoter region of the human keratin 6a gene. In mouse embryos, the transgene is expressed in the periderm (the outermost layer of embryonic epidermis), as are the endogenous keratin 6 α and β genes. A subset of periderm cells, localized to temporary epithelial fusions, is known to contain keratin 6 protein, and we find that these cells also harbor LacZ enzymatic activity. (C) 2001 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)65-69
Number of pages5
JournalMechanisms of Development
Volume100
Issue number1
DOIs
StatePublished - Jan 1 2001

Keywords

  • Keratin
  • Periderm
  • Skin
  • Temporary epithelial fusions
  • Transgenic mouse
  • Wound repair
  • β-Galactosidase

ASJC Scopus subject areas

  • Embryology
  • Developmental Biology

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