Abstract
We report the developmental regulation of a lacZ reporter transgene fused to the promoter region of the human keratin 6a gene. In mouse embryos, the transgene is expressed in the periderm (the outermost layer of embryonic epidermis), as are the endogenous keratin 6 α and β genes. A subset of periderm cells, localized to temporary epithelial fusions, is known to contain keratin 6 protein, and we find that these cells also harbor LacZ enzymatic activity. (C) 2001 Elsevier Science Ireland Ltd.
Original language | English (US) |
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Pages (from-to) | 65-69 |
Number of pages | 5 |
Journal | Mechanisms of Development |
Volume | 100 |
Issue number | 1 |
DOIs | |
State | Published - 2001 |
Externally published | Yes |
Keywords
- Keratin
- Periderm
- Skin
- Temporary epithelial fusions
- Transgenic mouse
- Wound repair
- β-Galactosidase
ASJC Scopus subject areas
- Embryology
- Developmental Biology