A Renal Olfactory Receptor Aids in Kidney Glucose Handling

Blythe D. Shepard, Lydie Cheval, Zita Peterlin, Stuart Firestein, Hermann Koepsell, Alain Doucet, Jennifer L. Pluznick

Research output: Contribution to journalArticlepeer-review

Abstract

Olfactory receptors (ORs) are G protein-coupled receptors which serve important sensory functions beyond their role as odorant detectors in the olfactory epithelium. Here we describe a novel role for one of these ORs, Olfr1393, as a regulator of renal glucose handling. Olfr1393 is specifically expressed in the kidney proximal tubule, which is the site of renal glucose reabsorption. Olfr1393 knockout mice exhibit urinary glucose wasting and improved glucose tolerance, despite euglycemia and normal insulin levels. Consistent with this phenotype, Olfr1393 knockout mice have a significant decrease in luminal expression of Sglt1, a key renal glucose transporter, uncovering a novel regulatory pathway involving Olfr1393 and Sglt1. In addition, by utilizing a large scale screen of over 1400 chemicals we reveal the ligand profile of Olfr1393 for the first time, offering new insight into potential pathways of physiological regulation for this novel signaling pathway.

Original languageEnglish (US)
Article number35215
JournalScientific reports
Volume6
DOIs
StatePublished - Oct 14 2016

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'A Renal Olfactory Receptor Aids in Kidney Glucose Handling'. Together they form a unique fingerprint.

Cite this