A recurrent pattern of chromosomal aberrations and immunophenotypic appearance defines anal squamous cell carcinomas

K. Heselmeyer, S. Du Manoir, H. Blegen, B. Friberg, C. Svensson, E. Schröck, T. Veldman, K. Shah, G. Auer, T. Ried

Research output: Contribution to journalArticlepeer-review

Abstract

Squamous cell carcinomas of the anus are rare neoplasias that account for about 3% of large bowel tumours, infections with human papillomaviruses are frequently detected in these cancers, suggesting that pathogenic pathways in anal carcinomas and in carcinomas of the uterine cervix are similar. Little is known regarding recurrent chromosomal aberrations in this subgroup of squamous cell carcinomas. We have applied comparative genomic hybridization to identify chromosomal gains and losses in 23 cases of anal carcinomas. A non-random copy number increase of chromosomes 17 and 19, and chromosome arm 3q was observed. Consistent losses were mapped to chromosome arms 4p, 11q, 13q and 18q. A majority of the rumours were aneuploid, and most of them showed increased proliferative activity as determined by staining for Ki-67 antigen. p53 expression was low or undetectable, and expression of p21/WAF-1 was increased in most tumours. Sixteen cancers were satisfactorily tested for the presence of HPV by consensus L1-primer polymerase chain reaction; nine were HPV positive, of which eight were positive for HPV 16.

Original languageEnglish (US)
Pages (from-to)1271-1278
Number of pages8
JournalBritish journal of cancer
Volume76
Issue number10
DOIs
StatePublished - 1997

Keywords

  • Anal carcinoma
  • Chromosome aberration
  • Comparative genomic hybridization
  • Human papillomavirus
  • Immunophenotype

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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