A real-time image-guided intraoperative high-dose-rate brachytherapy system

Shidong Li, Deborah Frassica, Theodore DeWeese, Ding Jen Lee, Jason Geng, Subir Nag

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To develop a real-time, image-guided intraoperative high-dose-rate brachytherapy system. Methods and Materials: The surface applicator, a catheter array on a 1-mm-thick soft and semitransparent silicone rubber sheet, was directly sutured on the surgical bed. A three-dimensional video camera was then used to instantly capture images of the catheters and the surgical surface. Tracing the catheters on the images allowed us to automatically determine the dwell source positions. Dwell times in the dwell positions were optimized to minimize the dose variation and deviation from the treatment prescription. A dose-texture plot was created to quantify the dose distribution. Results: Treatment planning time was reduced from hours to a few minutes. Phantom tests have shown that the new source localization is accurate with σ<1.5 mm. All hot spots and cold spots had been eliminated after the dwell-time optimization. Conclusions: This real-time, image-guided planning system can provide optimal image-guided intraoperative high-dose-rate brachytherapy with geometric and dosimetric improvements and a short planning time.

Original languageEnglish (US)
Pages (from-to)5-16
Number of pages12
JournalBrachytherapy
Volume2
Issue number1
DOIs
StatePublished - 2003

Keywords

  • High-dose-rate brachytherapy
  • Intraoperative radiotherapy
  • Iteration optimization
  • Real-time planning
  • Source localization

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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