@article{fa05b43430c14a659e40bbb3a08257fc,
title = "A rare null allele potentially encoding a dominant-negative TRIM5α protein in Baka pygmies",
abstract = "The global acquired immunodeficiency syndrome (AIDS) pandemic is thought to have arisen by the transmission of human immunodeficiency virus (HIV-1)-like viruses from chimpanzees in southeastern Cameroon to humans. TRIM5α is a restriction factor that can decrease the susceptibility of cells of particular mammalian species to retrovirus infection. A survey of TRIM5 genes in 127 indigenous individuals from southeastern Cameroon revealed that approximately 4% of the Baka pygmies studied were heterozygous for a rare variant with a stop codon in exon 8. The predicted product of this allele, TRIM5 R332X, is truncated in the functionally important B30.2(SPRY) domain, does not restrict retrovirus infection, and acts as a dominant-negative inhibitor of wild-type human TRIM5α. Thus, some indigenous African forest dwellers potentially exhibit diminished TRIM5α function; such genetic factors, along with the high frequency of exposure to chimpanzee body fluids, may have predisposed to the initial cross-species transmission of HIV-1-like viruses.",
keywords = "Africa, Cross-species transmission, HIV-1, Mutant, Polymorphism, Restriction factor, Susceptibility",
author = "Torimiro, {Judith N.} and Hassan Javanbakht and Felipe Diaz-Griffero and Jonghwa Kim and Carr, {Jean K.} and Mary Carrington and Julie Sawitzke and Burke, {Donald S.} and Wolfe, {Nathan D.} and Michael Dean and Joseph Sodroski",
note = "Funding Information: We thank Ms. Yvette McLaughlin and Ms. Elizabeth Carpelan for the preparation of the manuscript. This work has been supported, in part, by a Fellowship/Grant from the Fogarty International Center/USNIH: Grant # 2 D 43 TW000010-16 – AITRP; by the Intramural Research Program of the National Institutes of Health, National Cancer Institute, Center for Cancer Research; by the National Institutes of Health (AI063987, AI076094, AI067854 and a Center for AIDS Research Award AI060354); by the International AIDS Vaccine Initiative; by the Global Viral Forecasting Initiative; and by the late William F. McCarty-Cooper. This project has been funded in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U. S. Government.",
year = "2009",
month = aug,
day = "15",
doi = "10.1016/j.virol.2009.05.038",
language = "English (US)",
volume = "391",
pages = "140--147",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "1",
}