A rare case of hyponatremia from a hypothalamic lesion in a patient with multiple sclerosis

Joseph J. Sabatino; J. Kent Werner; Scott D. Newsome

doi:10.1177/1352458514546787

A rare case of hyponatremia from a hypothalamic lesion in a patient with multiple sclerosis

Joseph J. Sabatino, J. Kent Werner, Scott D. Newsome

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) can occur from a variety of neurologic and systemic processes; however, it has rarely been seen in multiple sclerosis (MS). We report a case of SIADH in a patient with MS and compare it with previously reported English-only cases. A 32-year-old woman experienced generalized fatigue followed by confusion and was found to have profound hyponatremia. Her work-up demonstrated SIADH secondary to a discrete enhancing hypothalamic lesion. Despite the seldom occurrence of SIADH in MS, hypothalamic lesions are more common than appreciated and should be considered in patients presenting with hyponatremia or endocrinopathy symptoms.

Original language	English (US)
Pages (from-to)	662-665
Number of pages	4
Journal	Multiple Sclerosis Journal
Volume	21
Issue number	5
DOIs	https://doi.org/10.1177/1352458514546787
State	Published - Apr 1 2015

Keywords

Multiple sclerosis
SIADH
hyponatremia
hypothalamic diseases
syndrome of inappropriate antidiuretic hormone secretion

ASJC Scopus subject areas

Neurology
Clinical Neurology

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title = "A rare case of hyponatremia from a hypothalamic lesion in a patient with multiple sclerosis",

abstract = "The syndrome of inappropriate antidiuretic hormone secretion (SIADH) can occur from a variety of neurologic and systemic processes; however, it has rarely been seen in multiple sclerosis (MS). We report a case of SIADH in a patient with MS and compare it with previously reported English-only cases. A 32-year-old woman experienced generalized fatigue followed by confusion and was found to have profound hyponatremia. Her work-up demonstrated SIADH secondary to a discrete enhancing hypothalamic lesion. Despite the seldom occurrence of SIADH in MS, hypothalamic lesions are more common than appreciated and should be considered in patients presenting with hyponatremia or endocrinopathy symptoms.",

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A rare case of hyponatremia from a hypothalamic lesion in a patient with multiple sclerosis

Abstract

Keywords

ASJC Scopus subject areas

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