A rare case of hyponatremia from a hypothalamic lesion in a patient with multiple sclerosis

Joseph J. Sabatino, J. Kent Werner, Scott D. Newsome

Research output: Contribution to journalArticlepeer-review

Abstract

The syndrome of inappropriate antidiuretic hormone secretion (SIADH) can occur from a variety of neurologic and systemic processes; however, it has rarely been seen in multiple sclerosis (MS). We report a case of SIADH in a patient with MS and compare it with previously reported English-only cases. A 32-year-old woman experienced generalized fatigue followed by confusion and was found to have profound hyponatremia. Her work-up demonstrated SIADH secondary to a discrete enhancing hypothalamic lesion. Despite the seldom occurrence of SIADH in MS, hypothalamic lesions are more common than appreciated and should be considered in patients presenting with hyponatremia or endocrinopathy symptoms.

Original languageEnglish (US)
Pages (from-to)662-665
Number of pages4
JournalMultiple Sclerosis Journal
Volume21
Issue number5
DOIs
StatePublished - Apr 1 2015

Keywords

  • Multiple sclerosis
  • SIADH
  • hyponatremia
  • hypothalamic diseases
  • syndrome of inappropriate antidiuretic hormone secretion

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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