A randomized trial of increasing patching for amblyopia

David K. Wallace, Elizabeth L. Lazar, Jonathan M. Holmes, Michael X Repka, Susan A. Cotter, Angela M. Chen, Raymond T. Kraker, Roy W. Beck, Michael P. Clarke, Ingryd J. Lorenzana, David B. Petersen, Joan T. Roberts, Donny W. Suh

Research output: Contribution to journalArticle

Abstract

Objective: After treatment with refractive correction and patching, some patients have residual amblyopia resulting from strabismus or anisometropia. We conducted a clinical trial to evaluate the effectiveness of increasing prescribed daily patching from 2 to 6 hours in children with stable residual amblyopia. Design: Prospective, randomized, multicenter clinical trial. Participants: A total of 169 children aged 3 to -2). Ten weeks after randomization, amblyopic eye VA had improved an average of 1.2 lines in the 6-hour group and 0.5 line in the 2-hour group (difference in mean VA adjusted for acuity at randomization = 0.6 line; 95% confidence interval, 0.3-1.0; P = 0.002). Improvement of 2 or more lines occurred in 40% of participants patched for 6 hours versus 18% of those who continued to patch for 2 hours (P = 0.003). Conclusions: When amblyopic eye VA stops improving with 2 hours of daily patching, increasing the daily patching dosage to 6 hours results in more improvement in VA after 10 weeks compared with continuing 2 hours daily. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

Original languageEnglish (US)
Pages (from-to)2270-2277
Number of pages8
JournalOphthalmology
Volume120
Issue number11
DOIs
StatePublished - Nov 2013

Fingerprint

Amblyopia
Random Allocation
Anisometropia
Strabismus
Disclosure
Multicenter Studies
Randomized Controlled Trials
Clinical Trials
Confidence Intervals
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Wallace, D. K., Lazar, E. L., Holmes, J. M., Repka, M. X., Cotter, S. A., Chen, A. M., ... Suh, D. W. (2013). A randomized trial of increasing patching for amblyopia. Ophthalmology, 120(11), 2270-2277. https://doi.org/10.1016/j.ophtha.2013.04.008

A randomized trial of increasing patching for amblyopia. / Wallace, David K.; Lazar, Elizabeth L.; Holmes, Jonathan M.; Repka, Michael X; Cotter, Susan A.; Chen, Angela M.; Kraker, Raymond T.; Beck, Roy W.; Clarke, Michael P.; Lorenzana, Ingryd J.; Petersen, David B.; Roberts, Joan T.; Suh, Donny W.

In: Ophthalmology, Vol. 120, No. 11, 11.2013, p. 2270-2277.

Research output: Contribution to journalArticle

Wallace, DK, Lazar, EL, Holmes, JM, Repka, MX, Cotter, SA, Chen, AM, Kraker, RT, Beck, RW, Clarke, MP, Lorenzana, IJ, Petersen, DB, Roberts, JT & Suh, DW 2013, 'A randomized trial of increasing patching for amblyopia', Ophthalmology, vol. 120, no. 11, pp. 2270-2277. https://doi.org/10.1016/j.ophtha.2013.04.008
Wallace DK, Lazar EL, Holmes JM, Repka MX, Cotter SA, Chen AM et al. A randomized trial of increasing patching for amblyopia. Ophthalmology. 2013 Nov;120(11):2270-2277. https://doi.org/10.1016/j.ophtha.2013.04.008
Wallace, David K. ; Lazar, Elizabeth L. ; Holmes, Jonathan M. ; Repka, Michael X ; Cotter, Susan A. ; Chen, Angela M. ; Kraker, Raymond T. ; Beck, Roy W. ; Clarke, Michael P. ; Lorenzana, Ingryd J. ; Petersen, David B. ; Roberts, Joan T. ; Suh, Donny W. / A randomized trial of increasing patching for amblyopia. In: Ophthalmology. 2013 ; Vol. 120, No. 11. pp. 2270-2277.
@article{31cafd2505e246b8be85ff09b27e4b3f,
title = "A randomized trial of increasing patching for amblyopia",
abstract = "Objective: After treatment with refractive correction and patching, some patients have residual amblyopia resulting from strabismus or anisometropia. We conducted a clinical trial to evaluate the effectiveness of increasing prescribed daily patching from 2 to 6 hours in children with stable residual amblyopia. Design: Prospective, randomized, multicenter clinical trial. Participants: A total of 169 children aged 3 to -2). Ten weeks after randomization, amblyopic eye VA had improved an average of 1.2 lines in the 6-hour group and 0.5 line in the 2-hour group (difference in mean VA adjusted for acuity at randomization = 0.6 line; 95{\%} confidence interval, 0.3-1.0; P = 0.002). Improvement of 2 or more lines occurred in 40{\%} of participants patched for 6 hours versus 18{\%} of those who continued to patch for 2 hours (P = 0.003). Conclusions: When amblyopic eye VA stops improving with 2 hours of daily patching, increasing the daily patching dosage to 6 hours results in more improvement in VA after 10 weeks compared with continuing 2 hours daily. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.",
author = "Wallace, {David K.} and Lazar, {Elizabeth L.} and Holmes, {Jonathan M.} and Repka, {Michael X} and Cotter, {Susan A.} and Chen, {Angela M.} and Kraker, {Raymond T.} and Beck, {Roy W.} and Clarke, {Michael P.} and Lorenzana, {Ingryd J.} and Petersen, {David B.} and Roberts, {Joan T.} and Suh, {Donny W.}",
year = "2013",
month = "11",
doi = "10.1016/j.ophtha.2013.04.008",
language = "English (US)",
volume = "120",
pages = "2270--2277",
journal = "Ophthalmology",
issn = "0161-6420",
publisher = "Elsevier Inc.",
number = "11",

}

TY - JOUR

T1 - A randomized trial of increasing patching for amblyopia

AU - Wallace, David K.

AU - Lazar, Elizabeth L.

AU - Holmes, Jonathan M.

AU - Repka, Michael X

AU - Cotter, Susan A.

AU - Chen, Angela M.

AU - Kraker, Raymond T.

AU - Beck, Roy W.

AU - Clarke, Michael P.

AU - Lorenzana, Ingryd J.

AU - Petersen, David B.

AU - Roberts, Joan T.

AU - Suh, Donny W.

PY - 2013/11

Y1 - 2013/11

N2 - Objective: After treatment with refractive correction and patching, some patients have residual amblyopia resulting from strabismus or anisometropia. We conducted a clinical trial to evaluate the effectiveness of increasing prescribed daily patching from 2 to 6 hours in children with stable residual amblyopia. Design: Prospective, randomized, multicenter clinical trial. Participants: A total of 169 children aged 3 to -2). Ten weeks after randomization, amblyopic eye VA had improved an average of 1.2 lines in the 6-hour group and 0.5 line in the 2-hour group (difference in mean VA adjusted for acuity at randomization = 0.6 line; 95% confidence interval, 0.3-1.0; P = 0.002). Improvement of 2 or more lines occurred in 40% of participants patched for 6 hours versus 18% of those who continued to patch for 2 hours (P = 0.003). Conclusions: When amblyopic eye VA stops improving with 2 hours of daily patching, increasing the daily patching dosage to 6 hours results in more improvement in VA after 10 weeks compared with continuing 2 hours daily. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

AB - Objective: After treatment with refractive correction and patching, some patients have residual amblyopia resulting from strabismus or anisometropia. We conducted a clinical trial to evaluate the effectiveness of increasing prescribed daily patching from 2 to 6 hours in children with stable residual amblyopia. Design: Prospective, randomized, multicenter clinical trial. Participants: A total of 169 children aged 3 to -2). Ten weeks after randomization, amblyopic eye VA had improved an average of 1.2 lines in the 6-hour group and 0.5 line in the 2-hour group (difference in mean VA adjusted for acuity at randomization = 0.6 line; 95% confidence interval, 0.3-1.0; P = 0.002). Improvement of 2 or more lines occurred in 40% of participants patched for 6 hours versus 18% of those who continued to patch for 2 hours (P = 0.003). Conclusions: When amblyopic eye VA stops improving with 2 hours of daily patching, increasing the daily patching dosage to 6 hours results in more improvement in VA after 10 weeks compared with continuing 2 hours daily. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.

UR - http://www.scopus.com/inward/record.url?scp=84887194101&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84887194101&partnerID=8YFLogxK

U2 - 10.1016/j.ophtha.2013.04.008

DO - 10.1016/j.ophtha.2013.04.008

M3 - Article

VL - 120

SP - 2270

EP - 2277

JO - Ophthalmology

JF - Ophthalmology

SN - 0161-6420

IS - 11

ER -