A randomized, placebo-controlled study of the effects of telcagepant on exercise time in patients with stable angina

B. R. Chaitman, A. P. Ho, M. O. Behm, J. F. Rowe, J. S. Palcza, T. Laethem, I. Heirman, D. L. Panebianco, Z. Kobalava, S. Y. Martsevich, A. L. Free, N. Bittar, S. G. Chrysant, T. W. Ho, J. A. Chodakewitz, M. G. Murphy, R. L. Blanchard

Research output: Contribution to journalArticle

Abstract

Telcagepant is a calcitonin gene-related peptide (CGRP) receptor antagonist being evaluated for acute migraine treatment. CGRP is a potent vasodilator that is elevated after myocardial infarction, and it delays ischemia during treadmill exercise. We tested the hypothesis that CGRP receptor antagonism does not reduce treadmill exercise time (TET). The effects of supratherapeutic doses of telcagepant on TET were assessed in a double-blind, randomized, placebo-controlled, two-period, crossover study in patients with stable angina and reproducible exercise-induced angina. Patients received telcagepant (600 mg, n = 46; and 900 mg, n = 14) or placebo and performed treadmill exercise at T max (2.5 h after the dose). The hypothesis that telcagepant does not reduce TET was supported if the lower bound of the two-sided 90% confidence interval (CI) for the mean treatment difference (telcagepant-placebo) in TET was more than 60 s. There were no significant between-treatment differences in TET (mean treatment difference: 6.90 (90% CI: 17.66, 3.86) seconds), maximum exercise heart rate, or time to 1-mm ST-segment depression using pooled data or with stratification for dose.

Original languageEnglish (US)
Pages (from-to)459-466
Number of pages8
JournalClinical pharmacology and therapeutics
Volume91
Issue number3
DOIs
StatePublished - Mar 1 2012

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Chaitman, B. R., Ho, A. P., Behm, M. O., Rowe, J. F., Palcza, J. S., Laethem, T., Heirman, I., Panebianco, D. L., Kobalava, Z., Martsevich, S. Y., Free, A. L., Bittar, N., Chrysant, S. G., Ho, T. W., Chodakewitz, J. A., Murphy, M. G., & Blanchard, R. L. (2012). A randomized, placebo-controlled study of the effects of telcagepant on exercise time in patients with stable angina. Clinical pharmacology and therapeutics, 91(3), 459-466. https://doi.org/10.1038/clpt.2011.246