A randomized feasibility pilot trial of hearing treatment for reducing cognitive decline: Results from the Aging and Cognitive Health Evaluation in Elders Pilot Study

Jennifer A. Deal, Marilyn S. Albert, Michelle Arnold, Shrikant I. Bangdiwala, Theresa Chisolm, Sonia Davis, Ann Eddins, Nancy W. Glynn, Adele M. Goman, Melissa Minotti, Thomas Mosley, George W. Rebok, Nicholas Reed, Elizabeth Rodgers, Victoria Sanchez, A. Richey Sharrett, Josef Coresh, Frank R. Lin

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction Hearing loss (HL) is prevalent and independently related to cognitive decline and dementia. There has never been a randomized trial to test if HL treatment could reduce cognitive decline in older adults. Methods A 40-person (aged 70–84 years) pilot study in Washington County, MD, was conducted. Participants were randomized 1:1 to a best practices hearing or successful aging intervention and followed for 6 months. clinicaltrials.gov Identifier: NCT02412254. Results The Aging and Cognitive Health Evaluation in Elders Pilot (ACHIEVE-P) Study demonstrated feasibility in recruitment, retention, and implementation of interventions with no treatment-related adverse events. A clear efficacy signal of the hearing intervention was observed in perceived hearing handicap (mean of 0.11 to −1.29 standard deviation [SD] units; lower scores better) and memory (mean of −0.10 SD to 0.38 SD). Discussion ACHIEVE-P sets the stage for the full-scale ACHIEVE trial (N = 850, recruitment beginning November 2017), the first randomized trial to determine efficacy of a best practices hearing (vs. successful aging) intervention on reducing cognitive decline in older adults with HL.

Original languageEnglish (US)
Pages (from-to)410-415
Number of pages6
JournalAlzheimer's and Dementia: Translational Research and Clinical Interventions
Volume3
Issue number3
DOIs
StatePublished - Sep 2017

Keywords

  • Clinical trials
  • Cognition
  • Dementia
  • Epidemiology
  • Hearing
  • Longitudinal study
  • Memory
  • Presbycusis

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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