A randomized, double-blind, placebo-controlled trial of the effect of zafirlukast on upper and lower respiratory responses to cat challenge

Wanda Phipatanakul, Peyton A. Eggleston, Mary Kay Conover-Walker, Jana Kesavanathan, Dennis Sweitzer, Robert A. Wood

Research output: Contribution to journalArticle

Abstract

Background: Zafirlukast, a leukotriene antagonist, has been shown to have protective effects against a variety of asthma triggers. Objective: Our purpose was to evaluate zafirlukast's effects on upper and lower airway responses to cat allergen exposure with use of a well-characterized cat exposure model. Methods: In a double-blind, placebo-controlled, cross-over trial 18 subjects with cat-induced asthma were randomly assigned to receive 1 week each of zafirlukast or placebo followed by a 1-hour cat challenge. Upper and lower respiratory symptoms were rated and spirometry and acoustic rhinometry were performed. Challenges were stopped early if the subject was too uncomfortable or had a >50% decrease in FEV1. Results: Overall changes in FEV1 were significantly different with zafirlukast treatment (P = .02). Significant differences in FEV1 change were detected at 15 and 30 minutes (P = .027 and .05, respectively) but not at 45 and 60 minutes. Changes in acoustic rhinometry were also significantly different at 15 and 30 minutes (P = .05 and .0005, respectively) but not at 45 and 60 minutes. Challenge length was significantly longer with zafirlukast versus placebo after adjustment for differences in allergen exposure (P = .022). Respiratory symptom scores were significantly different (lower respiratory, P < .001; upper respiratory, P = .038) through the first 30 minutes of the challenge after adjustment for allergen exposure. Conclusions: Zafirlukast was significantly more effective than placebo in preserving pulmonary function and nasal anatomy and extending challenge length when cat-sensitive asthmatic subjects were exposed to high levels of cat allergen.

Original languageEnglish (US)
Pages (from-to)704-710
Number of pages7
JournalJournal of Allergy and Clinical Immunology
Volume105
Issue number4
DOIs
StatePublished - Jan 1 2000

Keywords

  • Acoustic rhinometry
  • Cat allergen
  • Cat challenge
  • Zafirlukast

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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