A randomized controlled trial of panretinal photocoagulation with and without intravitreal ranibizumab in treatment-naive eyes with non-high-risk proliferative diabetic retinopathy

Daniel A. Ferraz, Lisa M. Vasquez, Rony C. Preti, Augusto Motta, Raafay Sophie, Millena G. Bittencourt, Yasir J. Sepah, Mário L.R. Monteiro, Quan Dong Nguyen, Walter Yukihiko Takahashi

Research output: Contribution to journalArticle

Abstract

PURPOSE:: To compare the efficacy of panretinal photocoagulation (PRP) and intravitreal ranibizumab injection with PRP alone in patients with treatment-naive bilateral non-high-risk proliferative diabetic retinopathy. METHODS:: Sixty eyes of 30 patients were randomized either to the study group (SG) receiving PRP plus 2 ranibizumab injections or to the control group (CG) receiving PRP alone. Mean change in best-corrected visual acuity and in optical coherence tomography were compared at baseline and 1, 3, and 6 months. RESULTS:: Best-corrected visual acuity was significantly better at 6 months in the SG; however, there was decrease in best-corrected visual acuity in the CG. Central macula thickness decreased significantly at 6 months in SG when compared with baseline (-47.6 μm, P < 0.001) and did not reveal significant difference in the CG. In eyes with diabetic macular edema, best-corrected visual acuity increased by 3.6 letters (P = 0.06) in the SG and decreased by 4.4 letters in the CG (P = 0.003). Central macula thickness decreased by 69.3 μm (P = 0.001) in the SG and decreased by 45.5 μm (P = 0.11) in the CG. CONCLUSION:: Intravitreal ranibizumab in combination with PRP can be an effective treatment in eyes with non-high-risk proliferative diabetic retinopathy and diabetic macular edema.

Original languageEnglish (US)
Pages (from-to)280-287
Number of pages8
JournalRetina
Volume35
Issue number2
DOIs
StatePublished - Feb 6 2015

Keywords

  • panretinal photocoagulation
  • proliferative diabetic retinopathy
  • ranibizumab

ASJC Scopus subject areas

  • Ophthalmology

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    Ferraz, D. A., Vasquez, L. M., Preti, R. C., Motta, A., Sophie, R., Bittencourt, M. G., Sepah, Y. J., Monteiro, M. L. R., Nguyen, Q. D., & Takahashi, W. Y. (2015). A randomized controlled trial of panretinal photocoagulation with and without intravitreal ranibizumab in treatment-naive eyes with non-high-risk proliferative diabetic retinopathy. Retina, 35(2), 280-287. https://doi.org/10.1097/IAE.0000000000000363