A randomized controlled trial comparing treatment with oral agents and basal insulin in elderly patients with type 2 diabetes in long-term care facilities

Francisco J. Pasquel, Winter Powell, Limin Peng, Theodore M. Johnson, Shadi Yarandi, Christopher Newton, Dawn Smiley, Marcos T. Toyoshima, Pedram Aram, Guillermo E. Umpierrez

Research output: Contribution to journalArticle

Abstract

Background: Managing hyperglycemia and diabetes is challenging in geriatric patients admitted to long-term care (LTC) facilities. Methods: This randomized control trial enrolled patients with type 2 diabetes (T2D) with blood glucose (BG) <180 mg/dL or glycated hemoglobin <7.5% to receive low-dose basal insulin (glargine, starting dose 0.1 U/kg/day) or oral antidiabetic drug (OAD) therapy as per primary care provider discretion for 26 weeks. Both groups received supplemental rapid-acting insulin before meals for BG <200 mg/dL. Primary end point was difference in glycemic control as measured by fasting and mean daily glucose concentration between groups. Results: A total of 150 patients (age: 79±8 years, body mass index: 30.1±6.5 kg/m2, duration of diabetes mellitus: 8.2±5.1 years, randomization BG: 194±97 mg/ dL) were randomized to basal insulin (n=75) and OAD therapy (n=75). There were no differences in the mean fasting BG (131±27 mg/dL vs 123±23 mg/dL, p=0.06) between insulin and OAD groups, but patients treated with insulin had greater mean daily BG (163±39 mg/dL vs 138±27 mg/dL, p<0.001) compared to those treated with OADs. There were no differences in the rate of hypoglycemia (>70 mg/dL) between insulin (27%) and OAD (31%) groups, p=0.58. In addition, there were no differences in the number of hospital complications, emergency room visits, and mortality between treatment groups. Conclusions: The results of this randomized study indicate that elderly patients with T2D in LTC facilities exhibited similar glycemic control, hypoglycemic events and complications when treated with either basal insulin or with oral antidiabetic drugs. Trial registration number: ClinicalTrials.gov Identifier: NCT01131052.

Original languageEnglish (US)
Article numbere000104
JournalBMJ Open Diabetes Research and Care
Volume3
Issue number1
DOIs
StatePublished - Jun 16 2015
Externally publishedYes

Fingerprint

Long-Term Care
Type 2 Diabetes Mellitus
Randomized Controlled Trials
Insulin
Hypoglycemic Agents
Hyperglycemia
Geriatrics
Blood Glucose
Hospital Emergency Service
Therapeutics
Mortality

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

A randomized controlled trial comparing treatment with oral agents and basal insulin in elderly patients with type 2 diabetes in long-term care facilities. / Pasquel, Francisco J.; Powell, Winter; Peng, Limin; Johnson, Theodore M.; Yarandi, Shadi; Newton, Christopher; Smiley, Dawn; Toyoshima, Marcos T.; Aram, Pedram; Umpierrez, Guillermo E.

In: BMJ Open Diabetes Research and Care, Vol. 3, No. 1, e000104, 16.06.2015.

Research output: Contribution to journalArticle

Pasquel, Francisco J. ; Powell, Winter ; Peng, Limin ; Johnson, Theodore M. ; Yarandi, Shadi ; Newton, Christopher ; Smiley, Dawn ; Toyoshima, Marcos T. ; Aram, Pedram ; Umpierrez, Guillermo E. / A randomized controlled trial comparing treatment with oral agents and basal insulin in elderly patients with type 2 diabetes in long-term care facilities. In: BMJ Open Diabetes Research and Care. 2015 ; Vol. 3, No. 1.
@article{c31d12dd98254ec3b6dd6ad337d1e8e9,
title = "A randomized controlled trial comparing treatment with oral agents and basal insulin in elderly patients with type 2 diabetes in long-term care facilities",
abstract = "Background: Managing hyperglycemia and diabetes is challenging in geriatric patients admitted to long-term care (LTC) facilities. Methods: This randomized control trial enrolled patients with type 2 diabetes (T2D) with blood glucose (BG) <180 mg/dL or glycated hemoglobin <7.5{\%} to receive low-dose basal insulin (glargine, starting dose 0.1 U/kg/day) or oral antidiabetic drug (OAD) therapy as per primary care provider discretion for 26 weeks. Both groups received supplemental rapid-acting insulin before meals for BG <200 mg/dL. Primary end point was difference in glycemic control as measured by fasting and mean daily glucose concentration between groups. Results: A total of 150 patients (age: 79±8 years, body mass index: 30.1±6.5 kg/m2, duration of diabetes mellitus: 8.2±5.1 years, randomization BG: 194±97 mg/ dL) were randomized to basal insulin (n=75) and OAD therapy (n=75). There were no differences in the mean fasting BG (131±27 mg/dL vs 123±23 mg/dL, p=0.06) between insulin and OAD groups, but patients treated with insulin had greater mean daily BG (163±39 mg/dL vs 138±27 mg/dL, p<0.001) compared to those treated with OADs. There were no differences in the rate of hypoglycemia (>70 mg/dL) between insulin (27{\%}) and OAD (31{\%}) groups, p=0.58. In addition, there were no differences in the number of hospital complications, emergency room visits, and mortality between treatment groups. Conclusions: The results of this randomized study indicate that elderly patients with T2D in LTC facilities exhibited similar glycemic control, hypoglycemic events and complications when treated with either basal insulin or with oral antidiabetic drugs. Trial registration number: ClinicalTrials.gov Identifier: NCT01131052.",
author = "Pasquel, {Francisco J.} and Winter Powell and Limin Peng and Johnson, {Theodore M.} and Shadi Yarandi and Christopher Newton and Dawn Smiley and Toyoshima, {Marcos T.} and Pedram Aram and Umpierrez, {Guillermo E.}",
year = "2015",
month = "6",
day = "16",
doi = "10.1136/bmjdrc-2015-000104",
language = "English (US)",
volume = "3",
journal = "BMJ Open Diabetes Research and Care",
issn = "2052-4897",
publisher = "BMJ Publishing Group",
number = "1",

}

TY - JOUR

T1 - A randomized controlled trial comparing treatment with oral agents and basal insulin in elderly patients with type 2 diabetes in long-term care facilities

AU - Pasquel, Francisco J.

AU - Powell, Winter

AU - Peng, Limin

AU - Johnson, Theodore M.

AU - Yarandi, Shadi

AU - Newton, Christopher

AU - Smiley, Dawn

AU - Toyoshima, Marcos T.

AU - Aram, Pedram

AU - Umpierrez, Guillermo E.

PY - 2015/6/16

Y1 - 2015/6/16

N2 - Background: Managing hyperglycemia and diabetes is challenging in geriatric patients admitted to long-term care (LTC) facilities. Methods: This randomized control trial enrolled patients with type 2 diabetes (T2D) with blood glucose (BG) <180 mg/dL or glycated hemoglobin <7.5% to receive low-dose basal insulin (glargine, starting dose 0.1 U/kg/day) or oral antidiabetic drug (OAD) therapy as per primary care provider discretion for 26 weeks. Both groups received supplemental rapid-acting insulin before meals for BG <200 mg/dL. Primary end point was difference in glycemic control as measured by fasting and mean daily glucose concentration between groups. Results: A total of 150 patients (age: 79±8 years, body mass index: 30.1±6.5 kg/m2, duration of diabetes mellitus: 8.2±5.1 years, randomization BG: 194±97 mg/ dL) were randomized to basal insulin (n=75) and OAD therapy (n=75). There were no differences in the mean fasting BG (131±27 mg/dL vs 123±23 mg/dL, p=0.06) between insulin and OAD groups, but patients treated with insulin had greater mean daily BG (163±39 mg/dL vs 138±27 mg/dL, p<0.001) compared to those treated with OADs. There were no differences in the rate of hypoglycemia (>70 mg/dL) between insulin (27%) and OAD (31%) groups, p=0.58. In addition, there were no differences in the number of hospital complications, emergency room visits, and mortality between treatment groups. Conclusions: The results of this randomized study indicate that elderly patients with T2D in LTC facilities exhibited similar glycemic control, hypoglycemic events and complications when treated with either basal insulin or with oral antidiabetic drugs. Trial registration number: ClinicalTrials.gov Identifier: NCT01131052.

AB - Background: Managing hyperglycemia and diabetes is challenging in geriatric patients admitted to long-term care (LTC) facilities. Methods: This randomized control trial enrolled patients with type 2 diabetes (T2D) with blood glucose (BG) <180 mg/dL or glycated hemoglobin <7.5% to receive low-dose basal insulin (glargine, starting dose 0.1 U/kg/day) or oral antidiabetic drug (OAD) therapy as per primary care provider discretion for 26 weeks. Both groups received supplemental rapid-acting insulin before meals for BG <200 mg/dL. Primary end point was difference in glycemic control as measured by fasting and mean daily glucose concentration between groups. Results: A total of 150 patients (age: 79±8 years, body mass index: 30.1±6.5 kg/m2, duration of diabetes mellitus: 8.2±5.1 years, randomization BG: 194±97 mg/ dL) were randomized to basal insulin (n=75) and OAD therapy (n=75). There were no differences in the mean fasting BG (131±27 mg/dL vs 123±23 mg/dL, p=0.06) between insulin and OAD groups, but patients treated with insulin had greater mean daily BG (163±39 mg/dL vs 138±27 mg/dL, p<0.001) compared to those treated with OADs. There were no differences in the rate of hypoglycemia (>70 mg/dL) between insulin (27%) and OAD (31%) groups, p=0.58. In addition, there were no differences in the number of hospital complications, emergency room visits, and mortality between treatment groups. Conclusions: The results of this randomized study indicate that elderly patients with T2D in LTC facilities exhibited similar glycemic control, hypoglycemic events and complications when treated with either basal insulin or with oral antidiabetic drugs. Trial registration number: ClinicalTrials.gov Identifier: NCT01131052.

UR - http://www.scopus.com/inward/record.url?scp=84974613545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84974613545&partnerID=8YFLogxK

U2 - 10.1136/bmjdrc-2015-000104

DO - 10.1136/bmjdrc-2015-000104

M3 - Article

AN - SCOPUS:84974613545

VL - 3

JO - BMJ Open Diabetes Research and Care

JF - BMJ Open Diabetes Research and Care

SN - 2052-4897

IS - 1

M1 - e000104

ER -