A Randomized Controlled Trial Comparing the Depth of Maximal Insertion Between Anterograde Single-Balloon Versus Spiral Enteroscopy

Robert A. Moran, Sindhu Barola, Joanna K. Law, Stuart K. Amateau, Daniil Rolshud, Erin Corless, Vandhana Kiswani, Vikesh Singh, Anthony N Kalloo, Mouen Khashab, Anne Marie Lennon, Patrick I. Okolo, Vivek Kumbhari

Research output: Contribution to journalArticle

Abstract

Background: Three device-assisted deep endoscopic platforms presently exist and are available for clinical use: double-balloon enteroscopy, single-balloon enteroscopy (SBE), and spiral enteroscopy (SE). In a retrospective study, SE was associated with a greater depth of maximal insertion (DMI) with similar diagnostic yields and procedure time as compared with SBE. Aims: This was a prospective, randomized comparison of SE and SBE with respect to DMI, diagnostic yield, procedure time, and rate of adverse events. Methods: Patients were prospectively randomized to undergo either anterograde SE or SBE. Patient demographics, indication for procedure, DMI, procedure time, therapeutic procedure time, adverse event, diagnostic findings, and therapeutic interventions were prospectively recorded. The primary outcome was DMI. Secondary outcomes included: procedure time; diagnostic yield; therapeutic yield and adverse event rates. Results: During the study period, 30 patients underwent deep enteroscopy (SE 13, SBE 17). The most common indication was gastrointestinal bleeding in both groups. There was no significant difference in the DMI between SE and SBE (330.0 ± 88.2 cm vs 285.3 ± 80.8 cm, P =.16). There was no difference between SE and SBE in procedure time (37.0 ± 10.5 vs 38.3 ± 12.4, P =.76), diagnostic yield (SE = 9 [69%] vs SBE = 7 [41%], P =.16), or therapeutic yield (SE = 6 [46%] vs SBE = 4 [24%], P =.26). There were no major adverse events in either group. Conclusions: Spiral enteroscopy and SBE are similar with respect to DMI, diagnostic yield, therapeutic yield, procedure time, and rate of adverse events. Small numbers prevent giving a definitive judgment and future adequately powered prospective study is required to confirm these findings.

Original languageEnglish (US)
JournalClinical Medicine Insights: Gastroenterology
Volume11
DOIs
StatePublished - Jan 22 2018

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Randomized Controlled Trials
Double-Balloon Enteroscopy
Single-Balloon Enteroscopy
Therapeutics
Retrospective Studies
Demography
Prospective Studies
Hemorrhage
Equipment and Supplies

Keywords

  • balloon
  • enteroscopy
  • randomized control trial
  • small bowel
  • Spiral

ASJC Scopus subject areas

  • Gastroenterology

Cite this

A Randomized Controlled Trial Comparing the Depth of Maximal Insertion Between Anterograde Single-Balloon Versus Spiral Enteroscopy. / Moran, Robert A.; Barola, Sindhu; Law, Joanna K.; Amateau, Stuart K.; Rolshud, Daniil; Corless, Erin; Kiswani, Vandhana; Singh, Vikesh; Kalloo, Anthony N; Khashab, Mouen; Marie Lennon, Anne; Okolo, Patrick I.; Kumbhari, Vivek.

In: Clinical Medicine Insights: Gastroenterology, Vol. 11, 22.01.2018.

Research output: Contribution to journalArticle

Moran, Robert A. ; Barola, Sindhu ; Law, Joanna K. ; Amateau, Stuart K. ; Rolshud, Daniil ; Corless, Erin ; Kiswani, Vandhana ; Singh, Vikesh ; Kalloo, Anthony N ; Khashab, Mouen ; Marie Lennon, Anne ; Okolo, Patrick I. ; Kumbhari, Vivek. / A Randomized Controlled Trial Comparing the Depth of Maximal Insertion Between Anterograde Single-Balloon Versus Spiral Enteroscopy. In: Clinical Medicine Insights: Gastroenterology. 2018 ; Vol. 11.
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abstract = "Background: Three device-assisted deep endoscopic platforms presently exist and are available for clinical use: double-balloon enteroscopy, single-balloon enteroscopy (SBE), and spiral enteroscopy (SE). In a retrospective study, SE was associated with a greater depth of maximal insertion (DMI) with similar diagnostic yields and procedure time as compared with SBE. Aims: This was a prospective, randomized comparison of SE and SBE with respect to DMI, diagnostic yield, procedure time, and rate of adverse events. Methods: Patients were prospectively randomized to undergo either anterograde SE or SBE. Patient demographics, indication for procedure, DMI, procedure time, therapeutic procedure time, adverse event, diagnostic findings, and therapeutic interventions were prospectively recorded. The primary outcome was DMI. Secondary outcomes included: procedure time; diagnostic yield; therapeutic yield and adverse event rates. Results: During the study period, 30 patients underwent deep enteroscopy (SE 13, SBE 17). The most common indication was gastrointestinal bleeding in both groups. There was no significant difference in the DMI between SE and SBE (330.0 ± 88.2 cm vs 285.3 ± 80.8 cm, P =.16). There was no difference between SE and SBE in procedure time (37.0 ± 10.5 vs 38.3 ± 12.4, P =.76), diagnostic yield (SE = 9 [69{\%}] vs SBE = 7 [41{\%}], P =.16), or therapeutic yield (SE = 6 [46{\%}] vs SBE = 4 [24{\%}], P =.26). There were no major adverse events in either group. Conclusions: Spiral enteroscopy and SBE are similar with respect to DMI, diagnostic yield, therapeutic yield, procedure time, and rate of adverse events. Small numbers prevent giving a definitive judgment and future adequately powered prospective study is required to confirm these findings.",
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AU - Moran, Robert A.

AU - Barola, Sindhu

AU - Law, Joanna K.

AU - Amateau, Stuart K.

AU - Rolshud, Daniil

AU - Corless, Erin

AU - Kiswani, Vandhana

AU - Singh, Vikesh

AU - Kalloo, Anthony N

AU - Khashab, Mouen

AU - Marie Lennon, Anne

AU - Okolo, Patrick I.

AU - Kumbhari, Vivek

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N2 - Background: Three device-assisted deep endoscopic platforms presently exist and are available for clinical use: double-balloon enteroscopy, single-balloon enteroscopy (SBE), and spiral enteroscopy (SE). In a retrospective study, SE was associated with a greater depth of maximal insertion (DMI) with similar diagnostic yields and procedure time as compared with SBE. Aims: This was a prospective, randomized comparison of SE and SBE with respect to DMI, diagnostic yield, procedure time, and rate of adverse events. Methods: Patients were prospectively randomized to undergo either anterograde SE or SBE. Patient demographics, indication for procedure, DMI, procedure time, therapeutic procedure time, adverse event, diagnostic findings, and therapeutic interventions were prospectively recorded. The primary outcome was DMI. Secondary outcomes included: procedure time; diagnostic yield; therapeutic yield and adverse event rates. Results: During the study period, 30 patients underwent deep enteroscopy (SE 13, SBE 17). The most common indication was gastrointestinal bleeding in both groups. There was no significant difference in the DMI between SE and SBE (330.0 ± 88.2 cm vs 285.3 ± 80.8 cm, P =.16). There was no difference between SE and SBE in procedure time (37.0 ± 10.5 vs 38.3 ± 12.4, P =.76), diagnostic yield (SE = 9 [69%] vs SBE = 7 [41%], P =.16), or therapeutic yield (SE = 6 [46%] vs SBE = 4 [24%], P =.26). There were no major adverse events in either group. Conclusions: Spiral enteroscopy and SBE are similar with respect to DMI, diagnostic yield, therapeutic yield, procedure time, and rate of adverse events. Small numbers prevent giving a definitive judgment and future adequately powered prospective study is required to confirm these findings.

AB - Background: Three device-assisted deep endoscopic platforms presently exist and are available for clinical use: double-balloon enteroscopy, single-balloon enteroscopy (SBE), and spiral enteroscopy (SE). In a retrospective study, SE was associated with a greater depth of maximal insertion (DMI) with similar diagnostic yields and procedure time as compared with SBE. Aims: This was a prospective, randomized comparison of SE and SBE with respect to DMI, diagnostic yield, procedure time, and rate of adverse events. Methods: Patients were prospectively randomized to undergo either anterograde SE or SBE. Patient demographics, indication for procedure, DMI, procedure time, therapeutic procedure time, adverse event, diagnostic findings, and therapeutic interventions were prospectively recorded. The primary outcome was DMI. Secondary outcomes included: procedure time; diagnostic yield; therapeutic yield and adverse event rates. Results: During the study period, 30 patients underwent deep enteroscopy (SE 13, SBE 17). The most common indication was gastrointestinal bleeding in both groups. There was no significant difference in the DMI between SE and SBE (330.0 ± 88.2 cm vs 285.3 ± 80.8 cm, P =.16). There was no difference between SE and SBE in procedure time (37.0 ± 10.5 vs 38.3 ± 12.4, P =.76), diagnostic yield (SE = 9 [69%] vs SBE = 7 [41%], P =.16), or therapeutic yield (SE = 6 [46%] vs SBE = 4 [24%], P =.26). There were no major adverse events in either group. Conclusions: Spiral enteroscopy and SBE are similar with respect to DMI, diagnostic yield, therapeutic yield, procedure time, and rate of adverse events. Small numbers prevent giving a definitive judgment and future adequately powered prospective study is required to confirm these findings.

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KW - randomized control trial

KW - small bowel

KW - Spiral

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