A Radium-223 microgenerator from cyclotron-produced trace Actinium-227

Diane S. Abou, Juile Pickett, John E. Mattson, Daniel L J Thorek

Research output: Contribution to journalArticle

Abstract

The alpha particle emitter Radium-223 dichloride (223RaCl2) has recently been approved for treatment of late-stage bone metastatic prostate cancer. There is considerable interest in studying this new agent outside of the clinical setting, however the supply of 223Ra is limited and expensive. We have engineered a 223Ra microgenerator using traces of 227Ac previously generated from cyclotron-produced 225Ac. Radiochemically pure 223RaCl2 was made, characterized, evaluated in vivo, and the source was recovered in high yield for regeneration of the microgenerator.

LanguageEnglish (US)
Pages36-42
Number of pages7
JournalApplied Radiation and Isotopes
Volume119
DOIs
StatePublished - Jan 1 2017

Fingerprint

actinium
radium
dichlorides
regeneration
bones
alpha particles
cyclotrons
emitters
cancer

Keywords

  • Ra
  • Ac
  • Th
  • Microgenerator
  • Purification

ASJC Scopus subject areas

  • Radiation

Cite this

A Radium-223 microgenerator from cyclotron-produced trace Actinium-227. / Abou, Diane S.; Pickett, Juile; Mattson, John E.; Thorek, Daniel L J.

In: Applied Radiation and Isotopes, Vol. 119, 01.01.2017, p. 36-42.

Research output: Contribution to journalArticle

@article{a9ed0e4de77f42dd8b43bf72e28eb2c6,
title = "A Radium-223 microgenerator from cyclotron-produced trace Actinium-227",
abstract = "The alpha particle emitter Radium-223 dichloride (223RaCl2) has recently been approved for treatment of late-stage bone metastatic prostate cancer. There is considerable interest in studying this new agent outside of the clinical setting, however the supply of 223Ra is limited and expensive. We have engineered a 223Ra microgenerator using traces of 227Ac previously generated from cyclotron-produced 225Ac. Radiochemically pure 223RaCl2 was made, characterized, evaluated in vivo, and the source was recovered in high yield for regeneration of the microgenerator.",
keywords = "Ra, Ac, Th, Microgenerator, Purification",
author = "Abou, {Diane S.} and Juile Pickett and Mattson, {John E.} and Thorek, {Daniel L J}",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.apradiso.2016.10.015",
language = "English (US)",
volume = "119",
pages = "36--42",
journal = "Applied Radiation and Isotopes",
issn = "0969-8043",
publisher = "Elsevier Limited",

}

TY - JOUR

T1 - A Radium-223 microgenerator from cyclotron-produced trace Actinium-227

AU - Abou,Diane S.

AU - Pickett,Juile

AU - Mattson,John E.

AU - Thorek,Daniel L J

PY - 2017/1/1

Y1 - 2017/1/1

N2 - The alpha particle emitter Radium-223 dichloride (223RaCl2) has recently been approved for treatment of late-stage bone metastatic prostate cancer. There is considerable interest in studying this new agent outside of the clinical setting, however the supply of 223Ra is limited and expensive. We have engineered a 223Ra microgenerator using traces of 227Ac previously generated from cyclotron-produced 225Ac. Radiochemically pure 223RaCl2 was made, characterized, evaluated in vivo, and the source was recovered in high yield for regeneration of the microgenerator.

AB - The alpha particle emitter Radium-223 dichloride (223RaCl2) has recently been approved for treatment of late-stage bone metastatic prostate cancer. There is considerable interest in studying this new agent outside of the clinical setting, however the supply of 223Ra is limited and expensive. We have engineered a 223Ra microgenerator using traces of 227Ac previously generated from cyclotron-produced 225Ac. Radiochemically pure 223RaCl2 was made, characterized, evaluated in vivo, and the source was recovered in high yield for regeneration of the microgenerator.

KW - Ra

KW - Ac

KW - Th

KW - Microgenerator

KW - Purification

UR - http://www.scopus.com/inward/record.url?scp=85001976325&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85001976325&partnerID=8YFLogxK

U2 - 10.1016/j.apradiso.2016.10.015

DO - 10.1016/j.apradiso.2016.10.015

M3 - Article

VL - 119

SP - 36

EP - 42

JO - Applied Radiation and Isotopes

T2 - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

SN - 0969-8043

ER -