A quick look at slow saccades after cardiac surgery: where is the lesion?

David Solomon; Stefano Ramat; R. John Leigh; David Zee

doi:10.1016/S0079-6123(08)00685-7

A quick look at slow saccades after cardiac surgery: where is the lesion?

David Solomon, Stefano Ramat, R. John Leigh, David Zee

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Saccadic palsy is a reported complication of cardiac surgery. One case that came to autopsy showed midline pontine gliosis; however, in most cases, no lesions are evident on neuroimaging. Since the saccadic palsy may range from single large slow saccades to a "staircase" of very small saccades that are normal in speed, it seems plausible that more than one mechanism is possible. Here we postulate that, in those patients who make a staircase of small saccades, loss of cerebellar Purkinje cells could cause fastigial nucleus neurons to fire prematurely, thereby decelerating saccades via inhibitory burst neurons.

Original language	English (US)
Title of host publication	Using Eye Movements as an Experimental Probe of Brain function A Symposium in Honor of Jean Buttner-Ennever
Publisher	Elsevier
Pages	587-590
Number of pages	4
ISBN (Print)	9780444531636
DOIs	https://doi.org/10.1016/S0079-6123(08)00685-7
State	Published - Jan 1 2008

Publication series

Name	Progress in Brain Research
Volume	171
ISSN (Print)	0079-6123

Keywords

excitatory burst neuron
fastigial nucleus
inhibitory burst neuron
omnipause neurons
Purkinje cells
saccades
saccadic hypometria
saccadic palsy

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0079-6123(08)00685-7

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A quick look at slow saccades after cardiac surgery : where is the lesion? / Solomon, David; Ramat, Stefano; Leigh, R. John; Zee, David.

Using Eye Movements as an Experimental Probe of Brain function A Symposium in Honor of Jean Buttner-Ennever. Elsevier, 2008. p. 587-590 (Progress in Brain Research; Vol. 171).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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