Abstract
Saccadic palsy is a reported complication of cardiac surgery. One case that came to autopsy showed midline pontine gliosis; however, in most cases, no lesions are evident on neuroimaging. Since the saccadic palsy may range from single large slow saccades to a "staircase" of very small saccades that are normal in speed, it seems plausible that more than one mechanism is possible. Here we postulate that, in those patients who make a staircase of small saccades, loss of cerebellar Purkinje cells could cause fastigial nucleus neurons to fire prematurely, thereby decelerating saccades via inhibitory burst neurons.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 587-590 |
| Number of pages | 4 |
| Journal | Progress in Brain Research |
| Volume | 171 |
| DOIs | |
| State | Published - 2008 |
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Keywords
- excitatory burst neuron
- fastigial nucleus
- inhibitory burst neuron
- omnipause neurons
- Purkinje cells
- saccades
- saccadic hypometria
- saccadic palsy
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
A quick look at slow saccades after cardiac surgery : where is the lesion? / Solomon, David; Ramat, Stefano; Leigh, R. John; Zee, David Samuel.
In: Progress in Brain Research, Vol. 171, 2008, p. 587-590.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A quick look at slow saccades after cardiac surgery
T2 - where is the lesion?
AU - Solomon, David
AU - Ramat, Stefano
AU - Leigh, R. John
AU - Zee, David Samuel
PY - 2008
Y1 - 2008
N2 - Saccadic palsy is a reported complication of cardiac surgery. One case that came to autopsy showed midline pontine gliosis; however, in most cases, no lesions are evident on neuroimaging. Since the saccadic palsy may range from single large slow saccades to a "staircase" of very small saccades that are normal in speed, it seems plausible that more than one mechanism is possible. Here we postulate that, in those patients who make a staircase of small saccades, loss of cerebellar Purkinje cells could cause fastigial nucleus neurons to fire prematurely, thereby decelerating saccades via inhibitory burst neurons.
AB - Saccadic palsy is a reported complication of cardiac surgery. One case that came to autopsy showed midline pontine gliosis; however, in most cases, no lesions are evident on neuroimaging. Since the saccadic palsy may range from single large slow saccades to a "staircase" of very small saccades that are normal in speed, it seems plausible that more than one mechanism is possible. Here we postulate that, in those patients who make a staircase of small saccades, loss of cerebellar Purkinje cells could cause fastigial nucleus neurons to fire prematurely, thereby decelerating saccades via inhibitory burst neurons.
KW - excitatory burst neuron
KW - fastigial nucleus
KW - inhibitory burst neuron
KW - omnipause neurons
KW - Purkinje cells
KW - saccades
KW - saccadic hypometria
KW - saccadic palsy
UR - http://www.scopus.com/inward/record.url?scp=49349088931&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=49349088931&partnerID=8YFLogxK
U2 - 10.1016/S0079-6123(08)00685-7
DO - 10.1016/S0079-6123(08)00685-7
M3 - Article
C2 - 18718359
AN - SCOPUS:49349088931
VL - 171
SP - 587
EP - 590
JO - Progress in Brain Research
JF - Progress in Brain Research
SN - 0079-6123
ER -