A Quantitative Histological Evaluation of the Dilated Ureter of Childhood. II: Ectopia, Posterior Urethral Valves and the Prune Belly Syndrome

John Phillip Gearhart, Benjamin R. Lee, Alan Wayne Partin, Jonathan Ira Epstein, John A. Gosling, Barry A. Kogan

Research output: Contribution to journalArticle


A quantitative histological study was performed on specimens of 33 ureters obtained from 14 male and 19 female patients 5 days to 14 years old (mean age 1.2 years). A high resolution color image video analysis system was used to quantify and compare collagen and smooth muscle components of the muscularis layers to normal control ureters from patients of similar ages. In comparing ureters with ectopia (7), ureters with ectopic ureteroceles (20) and control ureters (4) there was not a statistically different collagen-to-smooth muscle ratio among the groups. In the patients with posterior urethral valves the amount of collagen and smooth muscle was not statistically different from controls (p >0.01), although the collagen-to-smooth muscle ratio was increased. The 4 patients with the prune belly syndrome had a collagen-to-smooth muscle ratio that was markedly elevated (1.21 versus 0.39) compared with controls. When this group was analyzed as 2 separate groups (obstructed versus refluxing ureters) the difference was more apparent (p

Original languageEnglish (US)
Pages (from-to)172-176
Number of pages5
JournalJournal of Urology
Issue number1
StatePublished - 1995


ASJC Scopus subject areas

  • Urology

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