A quantitative histological analysis of the dilated ureter of childhood

B. R. Lee, Alan Wayne Partin, Jonathan Ira Epstein, D. M. Quinlan, J. A. Gosling, John Phillip Gearhart

Research output: Contribution to journalArticle

Abstract

A quantitative histological study of the dilated ureter of childhood was performed on 26 ureters. The specimens were from 15 male and 11 female patients 10 days to 12 years old (mean age 2.0 years). A color image analysis system was used to examine and compare collagen and smooth muscle components of the muscularis layers to normal control ureters of similar age. In comparing primary obstructed (12) to primary refluxing (14) megaureters and control ureters (6), there was a statistically different collagen-to-smooth muscle ratio (p 0.01). The increased tissue matrix ratio of 2.0 ± 0.35 (collagen-to-smooth muscle) in the refluxing megaureter group compared to 0.78 ± 0.22 in the obstructed megaureter group and 0.52 ± 0.12 in controls was found to be due not only to a marked increase in collagen but also a significant decrease in the smooth muscle component of the tissue. Primary obstructed and normal control ureters had similar quantitative amounts of smooth muscle with 60 ± 5% and 61 ± 6%, respectively, while refluxing megaureters had only 40 ± 5% smooth muscle. The percentage collagen was 36 ± 5 in the obstructed megaureter group and 30 ± 5 in controls, with refluxing megaureters having 58 ± 5% collagen on analysis. Our findings emphasize the significant differences in the structural components (collagen and smooth muscle) of the dilated ureter of childhood, and provide us with further insight into the pathological nature of these dilated ureters and their surgical repair.

Original languageEnglish (US)
Pages (from-to)1482-1486
Number of pages5
JournalJournal of Urology
Volume148
Issue number5 I
StatePublished - 1992

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Ureter
Smooth Muscle
Collagen
Color
Muscles

Keywords

  • pediatrics
  • ureter
  • ureteral diseases
  • ureteral obstruction

ASJC Scopus subject areas

  • Urology

Cite this

A quantitative histological analysis of the dilated ureter of childhood. / Lee, B. R.; Partin, Alan Wayne; Epstein, Jonathan Ira; Quinlan, D. M.; Gosling, J. A.; Gearhart, John Phillip.

In: Journal of Urology, Vol. 148, No. 5 I, 1992, p. 1482-1486.

Research output: Contribution to journalArticle

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AU - Gearhart, John Phillip

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