A public database for gene expression in human cancers

Anita Lal, Alex E. Lash, Stephen F. Altschul, Victor E Velculescu, Lin Zhang, Roger E. McLendon, Marco A. Marra, Christa Prange, Patrice J. Morin, Kornelia Polyak, Nickolas Papadopoulos, Bert Vogelstein, Kenneth W Kinzler, Robert L. Strausberg, Gregory J Riggins

Research output: Contribution to journalArticle

Abstract

A public database, SAGEmap, was created as a component of the Cancer Genome Anatomy Project to provide a central location for depositing, retrieving, and analyzing human gene expression data. This database uses serial analysis of gene expression to quantify transcript levels in both malignant and normal human tissues. By accessing SAGEmap (http://www.ncbi.nlm.nih-gov/SAGE) the user can compare transcript populations between any of the posted libraries. As an initial demonstration of the database's utility, gene expression in human glioblastomas was compared with that of normal brain white matter. Of the 47,174 unique transcripts expressed in these two tissues, 471 (1.0%) were differentially expressed by more than 5-fold (P <0.001). Classification of these genes revealed functions consistent with the biological properties of glioblastomas, in particular: angiogenesis, transcription, and cell cycle related genes.

Original languageEnglish (US)
Pages (from-to)5403-5407
Number of pages5
JournalCancer Research
Volume59
Issue number21
StatePublished - Nov 1 1999

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Databases
Glioblastoma
Gene Expression
Genome Components
cdc Genes
Neoplasms
Libraries
Anatomy
Brain
Population
Genes
White Matter

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Lal, A., Lash, A. E., Altschul, S. F., Velculescu, V. E., Zhang, L., McLendon, R. E., ... Riggins, G. J. (1999). A public database for gene expression in human cancers. Cancer Research, 59(21), 5403-5407.

A public database for gene expression in human cancers. / Lal, Anita; Lash, Alex E.; Altschul, Stephen F.; Velculescu, Victor E; Zhang, Lin; McLendon, Roger E.; Marra, Marco A.; Prange, Christa; Morin, Patrice J.; Polyak, Kornelia; Papadopoulos, Nickolas; Vogelstein, Bert; Kinzler, Kenneth W; Strausberg, Robert L.; Riggins, Gregory J.

In: Cancer Research, Vol. 59, No. 21, 01.11.1999, p. 5403-5407.

Research output: Contribution to journalArticle

Lal, A, Lash, AE, Altschul, SF, Velculescu, VE, Zhang, L, McLendon, RE, Marra, MA, Prange, C, Morin, PJ, Polyak, K, Papadopoulos, N, Vogelstein, B, Kinzler, KW, Strausberg, RL & Riggins, GJ 1999, 'A public database for gene expression in human cancers', Cancer Research, vol. 59, no. 21, pp. 5403-5407.
Lal A, Lash AE, Altschul SF, Velculescu VE, Zhang L, McLendon RE et al. A public database for gene expression in human cancers. Cancer Research. 1999 Nov 1;59(21):5403-5407.
Lal, Anita ; Lash, Alex E. ; Altschul, Stephen F. ; Velculescu, Victor E ; Zhang, Lin ; McLendon, Roger E. ; Marra, Marco A. ; Prange, Christa ; Morin, Patrice J. ; Polyak, Kornelia ; Papadopoulos, Nickolas ; Vogelstein, Bert ; Kinzler, Kenneth W ; Strausberg, Robert L. ; Riggins, Gregory J. / A public database for gene expression in human cancers. In: Cancer Research. 1999 ; Vol. 59, No. 21. pp. 5403-5407.
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