A PTCH1 homolog transcriptionally activated by p53 suppresses hedgehog signaling

Jon H. Chung, Andrew R. Larsen, Evan Chen, Fred Bunz

Research output: Contribution to journalArticle

Abstract

Background: p53 activates transcription of downstream target genes that contribute to tumor suppression. Results: The expression of PTCH53, a structural and functional homolog of PTCH1, is highly responsive to p53 in diverse cells and tissues. Conclusion: p53 can suppress canonical Hedgehog signaling via induction of PTCH53.Significance: PTCH53 is a new mediator by which p53 can suppress oncogenic Hedgehog signals.

Original languageEnglish (US)
Pages (from-to)33020-33031
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number47
DOIs
Publication statusPublished - Nov 21 2014

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ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

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