A PTCH1 homolog transcriptionally activated by p53 suppresses hedgehog signaling

Jon H. Chung, Andrew R. Larsen, Evan Chen, Fred Bunz

Research output: Contribution to journalArticle

Abstract

Background: p53 activates transcription of downstream target genes that contribute to tumor suppression. Results: The expression of PTCH53, a structural and functional homolog of PTCH1, is highly responsive to p53 in diverse cells and tissues. Conclusion: p53 can suppress canonical Hedgehog signaling via induction of PTCH53.Significance: PTCH53 is a new mediator by which p53 can suppress oncogenic Hedgehog signals.

Original languageEnglish (US)
Pages (from-to)33020-33031
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number47
DOIs
StatePublished - Nov 21 2014

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Transcription
Tumors
Genes
Tissue
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology
  • Medicine(all)

Cite this

A PTCH1 homolog transcriptionally activated by p53 suppresses hedgehog signaling. / Chung, Jon H.; Larsen, Andrew R.; Chen, Evan; Bunz, Fred.

In: Journal of Biological Chemistry, Vol. 289, No. 47, 21.11.2014, p. 33020-33031.

Research output: Contribution to journalArticle

Chung, Jon H. ; Larsen, Andrew R. ; Chen, Evan ; Bunz, Fred. / A PTCH1 homolog transcriptionally activated by p53 suppresses hedgehog signaling. In: Journal of Biological Chemistry. 2014 ; Vol. 289, No. 47. pp. 33020-33031.
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