A proteomic primer for the clinician

Yurong Guo, Zongming Fu, Jennifer E. Van Eyk

Research output: Contribution to journalReview article

Abstract

Proteomics is a rapidly developing field and it opens new horizons in many research areas of life sciences. In the field of medicine, proteomics promises to accelerate the discovery ofnew drug targets and protein disease markers useful for in vitro diagnosis. In this article, we review the current proteomics technologies for biomarker discovery and validation, which include two-dimensional gel electrophoresis, one- and two-dimensional liquid chromatography, and proteomic microarrays. We will also review proteomic strategies for protein-protein interactions and identification of posttranslational modifications. Selection of the more effective technology or combination of technologies is required to maximize the interpretation and utility of the data.

Original languageEnglish (US)
Pages (from-to)9-17
Number of pages9
JournalProceedings of the American Thoracic Society
Volume4
Issue number1
DOIs
StatePublished - Jan 1 2007

Keywords

  • 2D electrophoresis
  • Multiple dimensional chromatography
  • Post-translational modification
  • Proteomic microarrays
  • Proteomics

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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