Abstract
Does a protein's secondary structure determine its three-dimensional fold? This question is tested directly by analyzing proteins of known structure and constructing a taxonomy based solely on secondary structure. The taxonomy is generated automatically, and it takes the form of a tree in which proteins with similar secondary structure occupy neighboring leaves, our tree is largely in agreement with results from the structural classification of proteins (SCOP), a multidimensional classification based on homologous sequences, full three-dimensional structure, information about chemistry and evolution, and human judgment. Our findings suggest a simple mechanism of protein evolution.
Original language | English (US) |
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Pages (from-to) | 672-682 |
Number of pages | 11 |
Journal | Nature Structural Biology |
Volume | 6 |
Issue number | 7 |
DOIs | |
State | Published - 1999 |
ASJC Scopus subject areas
- Structural Biology
- Biochemistry
- Genetics