A protein taxonomy based on secondary structure

Teresa Przytycka, Rajeev Aurora, George D Rose

Research output: Contribution to journalArticle

Abstract

Does a protein's secondary structure determine its three-dimensional fold? This question is tested directly by analyzing proteins of known structure and constructing a taxonomy based solely on secondary structure. The taxonomy is generated automatically, and it takes the form of a tree in which proteins with similar secondary structure occupy neighboring leaves, our tree is largely in agreement with results from the structural classification of proteins (SCOP), a multidimensional classification based on homologous sequences, full three-dimensional structure, information about chemistry and evolution, and human judgment. Our findings suggest a simple mechanism of protein evolution.

Original languageEnglish (US)
Pages (from-to)672-682
Number of pages11
JournalNature Structural Biology
Volume6
Issue number7
DOIs
StatePublished - 1999

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Taxonomies
Proteins
Secondary Protein Structure
Sequence Homology

ASJC Scopus subject areas

  • Biochemistry
  • Structural Biology
  • Genetics

Cite this

A protein taxonomy based on secondary structure. / Przytycka, Teresa; Aurora, Rajeev; Rose, George D.

In: Nature Structural Biology, Vol. 6, No. 7, 1999, p. 672-682.

Research output: Contribution to journalArticle

Przytycka, Teresa ; Aurora, Rajeev ; Rose, George D. / A protein taxonomy based on secondary structure. In: Nature Structural Biology. 1999 ; Vol. 6, No. 7. pp. 672-682.
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