A protein taxonomy based on secondary structure

Teresa Przytycka, Rajeev Aurora, George D. Rose

Research output: Contribution to journalArticlepeer-review

Abstract

Does a protein's secondary structure determine its three-dimensional fold? This question is tested directly by analyzing proteins of known structure and constructing a taxonomy based solely on secondary structure. The taxonomy is generated automatically, and it takes the form of a tree in which proteins with similar secondary structure occupy neighboring leaves, our tree is largely in agreement with results from the structural classification of proteins (SCOP), a multidimensional classification based on homologous sequences, full three-dimensional structure, information about chemistry and evolution, and human judgment. Our findings suggest a simple mechanism of protein evolution.

Original languageEnglish (US)
Pages (from-to)672-682
Number of pages11
JournalNature structural biology
Volume6
Issue number7
DOIs
StatePublished - Jul 19 1999

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Genetics

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