TY - JOUR
T1 - A prospective study on pulse wave velocity (PWV) and response to anti-hypertensive treatments
T2 - PWV determines BP control
AU - Zheng, Meili
AU - Huo, Yong
AU - Wang, Xiaobin
AU - Xu, Xin
AU - Qin, Xianhui
AU - Tang, Genfu
AU - Xing, Houxun
AU - Fan, Fangfang
AU - Li, Jianping
AU - Zhang, Yan
AU - Wang, Binyan
AU - Xu, Xiping
AU - Yang, Xinchun
AU - Chen, Yundai
AU - Qian, Geng
N1 - Funding Information:
This research was supported by the Ministry of Science and Technology of the People's Republic of China ( 2012zx 09101105 ); and the Major State Basic Research Development Program of China (973 program, No. 2012CB517703 )
Publisher Copyright:
© 2014 Elsevier Ireland Ltd. All rights reserved.
PY - 2015/1/15
Y1 - 2015/1/15
N2 - Objectives Recent data indicate that hypertension is not well controlled in many populations throughout the world. The factors that influence individual response to anti-hypertensive treatment need to be clarified. Pulse wave velocity (PWV), as a marker of arterial stiffness, has been demonstrated to have important relationships with BP progression; however, little information is available on the role of PWV in blood pressure (BP) control. We aimed to assess BP control during the run-in treatment period in the China Stroke Primary Prevention Trial (CSPPT).Methods and results These analyses included a total of 3056 treated hypertensive subjects (age: 59.6 ± 7.5 years, male/female 1339/1717) with PWV measured at baseline. The average BP at enrollment was 166/95 mm Hg, and declined to 141/85 mm Hg after short-term antihypertensive treatment (a median follow-up of 20 days). There was an inverse relationship between PWV level and BP reduction during the treatment, most notably for systolic BP (with estimated coefficients of - 9.01 (P < 0.001) for the top quartile, as compared to the bottom quartile). The association did not differ significantly by gender or types of antihypertensive drugs. Factors related to smaller BP decline were low baseline BP, high baseline PWV, high body mass index, high creatinine, use of fewer types of antihypertensive drug, high heart rate (only for SBP), high homocysteine and low age (only for DBP).Conclusion PWV appears to be an independent determinant of individual response to anti-hypertensive treatment.
AB - Objectives Recent data indicate that hypertension is not well controlled in many populations throughout the world. The factors that influence individual response to anti-hypertensive treatment need to be clarified. Pulse wave velocity (PWV), as a marker of arterial stiffness, has been demonstrated to have important relationships with BP progression; however, little information is available on the role of PWV in blood pressure (BP) control. We aimed to assess BP control during the run-in treatment period in the China Stroke Primary Prevention Trial (CSPPT).Methods and results These analyses included a total of 3056 treated hypertensive subjects (age: 59.6 ± 7.5 years, male/female 1339/1717) with PWV measured at baseline. The average BP at enrollment was 166/95 mm Hg, and declined to 141/85 mm Hg after short-term antihypertensive treatment (a median follow-up of 20 days). There was an inverse relationship between PWV level and BP reduction during the treatment, most notably for systolic BP (with estimated coefficients of - 9.01 (P < 0.001) for the top quartile, as compared to the bottom quartile). The association did not differ significantly by gender or types of antihypertensive drugs. Factors related to smaller BP decline were low baseline BP, high baseline PWV, high body mass index, high creatinine, use of fewer types of antihypertensive drug, high heart rate (only for SBP), high homocysteine and low age (only for DBP).Conclusion PWV appears to be an independent determinant of individual response to anti-hypertensive treatment.
KW - Arterial stiffness
KW - Blood pressure
KW - Hypertension
KW - Pulse wave velocity
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U2 - 10.1016/j.ijcard.2014.10.049
DO - 10.1016/j.ijcard.2014.10.049
M3 - Article
C2 - 25464260
AN - SCOPUS:84916200132
SN - 0167-5273
VL - 178
SP - 226
EP - 231
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -