A prospective study of the natural history of large local reactions after Hymenoptera stings in children

David F. Graft, Kenneth C. Schuberth, Anne Kagey-Sobotka, Kathy A. Kwiterovich, Yaffa Niv, Lawrence M. Lichtenstein, Martin D. Valentine

Research output: Contribution to journalArticle


Large local reactions are a frequent occurrence after insect stings. We prospectively studied the demography, immunology, and significance of these reactions in the pediatric age group. Most children (83%) who have had large local reactions have positive skin test results to one or more venoms. Elevated amounts of venom-specific IgE antibody are usually present. Over 3 to 5 years, allergic sensitivity declines, as evidenced by less positive skin test results and lower levels of antivenom IgE antibodies. Most significantly, of 113 repeat stings, only 2% resulted in a systemic reaction.

Original languageEnglish (US)
Pages (from-to)664-668
Number of pages5
JournalThe Journal of pediatrics
Issue number5
StatePublished - May 1984


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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