A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma

Qing Lan, Unhee Lim, Chin San Liu, Stephanie J. Weinstein, Stephen Chanock, Matthew R. Bonner, Jarmo Virtamo, Demetrius Albanes, Nathaniel Rothman

Research output: Contribution to journalArticlepeer-review

Abstract

MitochondrialDNA(mtDNA) copy number is increased in patients with chronic lymphocytic leukemia (CLL), in Burkitt lymphoma andEpstein-Barr virus-transformed lymphoblastoid cell lines, and in T cells activated via the T-cell receptor.We hypothesized that having a higher mtDNA copy number in peripheral white blood cellDNAfrom healthy subjects would be associated with future risk of non-Hodgkin lymphoma (NHL). We analyzed mtDNA copy number in 104 incident male NHL cases and 104 matched controls within the prospective Alpha-Tocopherol, Beta-Carotene (ATBC) Cancer Prevention cohort. There was a doseresponse relationship between tertiles of mtDNA copy number and risk of NHL (odds ratio [OR], 95% confidence interval [CI]: 1.0; 1.4 [0.7-2.8]; and 2.4 [1.0-5.5], respectively; Ptrend = .046). The effect was most pronounced for the CLL/small lymphocytic lymphoma (SLL) subtype (OR: 1.0; 3.2 [0.7-15.7]; 14.1 [1.9-103.2]; Ptrend = .009). These results suggest that mtDNA copy number could be associated with the risk of NHL, particularly CLL/ SLL.

Original languageEnglish (US)
Pages (from-to)4247-4249
Number of pages3
JournalBlood
Volume112
Issue number10
DOIs
StatePublished - Nov 15 2008

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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