A prospective study of lycopene and tomato product intake and risk of prostate cancer

Victoria A. Kirsh, Susan T. Mayne, Ulrike Peters, Nilanjan Chatterjee, Michael F. Leitzmann, L. Beth Dixon, Donald A. Urban, E. David Crawford, Richard B. Hayes

Research output: Contribution to journalArticle

Abstract

Background: Dietary lycopene and tomato products may reduce risk of prostate cancer; however, uncertainty remains about this possible association. Methods: We evaluated the association between intake of lycopene and specific tomato products and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, a multicenter study designed to investigate cancer early detection methods and etiologic determinants. Participants completed both a general risk factor and a 137-item food frequency questionnaire at baseline. A total of 1,338 cases of prostate cancer were identified among 29,361 men during an average of 4.2 years of follow-up. Results: Lycopene intake was not associated with prostate cancer risk. Reduced risks were also not found for total tomato servings or for most tomato-based foods. Statistically nonsignificant inverse associations were noted for pizza [all prostate cancer: relative risk (RR), 0.83; 95% confidence interval (95% CI), 0.67-1.03 for ≥1 serving/wk versus <0.5 serving/mo; Ptrend = 0.06 and advanced prostate cancer: RR, 0.79; 95% CI, 0.56-1.10; Ptrend = 0.12] and spaghetti/tomato sauce consumption (advanced prostate cancer. RR = 0.81, 95% CI, 0.57-1.16 for ≥2 servings/wk versus <1 serving/mo; Ptrend = 0.31). Among men with a family history of prostate cancer, risks were decreased in relation to increased consumption of lycopene (Ptrend = 0.04) and specific tomato-based foods commonly eaten with fat (spaghetti, P trend = 0.12; pizza, Ptrend = 0.15; lasagna, P trend = 0.02). Conclusions: This large study does not support the hypothesis that greater lycopene/tomato product consumption protects from prostate cancer. Evidence for protective associations in subjects with a family history of prostate cancer requires further corroboration.

Original languageEnglish (US)
Pages (from-to)92-98
Number of pages7
JournalCancer Epidemiology Biomarkers and Prevention
Volume15
Issue number1
DOIs
StatePublished - Jan 2006
Externally publishedYes

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Lycopersicon esculentum
Prostatic Neoplasms
Prospective Studies
Confidence Intervals
Early Detection of Cancer
Food
lycopene
Ovarian Neoplasms
Multicenter Studies
Uncertainty
Colorectal Neoplasms
Lung Neoplasms
Fats

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

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A prospective study of lycopene and tomato product intake and risk of prostate cancer. / Kirsh, Victoria A.; Mayne, Susan T.; Peters, Ulrike; Chatterjee, Nilanjan; Leitzmann, Michael F.; Dixon, L. Beth; Urban, Donald A.; Crawford, E. David; Hayes, Richard B.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 15, No. 1, 01.2006, p. 92-98.

Research output: Contribution to journalArticle

Kirsh, VA, Mayne, ST, Peters, U, Chatterjee, N, Leitzmann, MF, Dixon, LB, Urban, DA, Crawford, ED & Hayes, RB 2006, 'A prospective study of lycopene and tomato product intake and risk of prostate cancer', Cancer Epidemiology Biomarkers and Prevention, vol. 15, no. 1, pp. 92-98. https://doi.org/10.1158/1055-9965.EPI-05-0563
Kirsh, Victoria A. ; Mayne, Susan T. ; Peters, Ulrike ; Chatterjee, Nilanjan ; Leitzmann, Michael F. ; Dixon, L. Beth ; Urban, Donald A. ; Crawford, E. David ; Hayes, Richard B. / A prospective study of lycopene and tomato product intake and risk of prostate cancer. In: Cancer Epidemiology Biomarkers and Prevention. 2006 ; Vol. 15, No. 1. pp. 92-98.
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abstract = "Background: Dietary lycopene and tomato products may reduce risk of prostate cancer; however, uncertainty remains about this possible association. Methods: We evaluated the association between intake of lycopene and specific tomato products and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, a multicenter study designed to investigate cancer early detection methods and etiologic determinants. Participants completed both a general risk factor and a 137-item food frequency questionnaire at baseline. A total of 1,338 cases of prostate cancer were identified among 29,361 men during an average of 4.2 years of follow-up. Results: Lycopene intake was not associated with prostate cancer risk. Reduced risks were also not found for total tomato servings or for most tomato-based foods. Statistically nonsignificant inverse associations were noted for pizza [all prostate cancer: relative risk (RR), 0.83; 95{\%} confidence interval (95{\%} CI), 0.67-1.03 for ≥1 serving/wk versus <0.5 serving/mo; Ptrend = 0.06 and advanced prostate cancer: RR, 0.79; 95{\%} CI, 0.56-1.10; Ptrend = 0.12] and spaghetti/tomato sauce consumption (advanced prostate cancer. RR = 0.81, 95{\%} CI, 0.57-1.16 for ≥2 servings/wk versus <1 serving/mo; Ptrend = 0.31). Among men with a family history of prostate cancer, risks were decreased in relation to increased consumption of lycopene (Ptrend = 0.04) and specific tomato-based foods commonly eaten with fat (spaghetti, P trend = 0.12; pizza, Ptrend = 0.15; lasagna, P trend = 0.02). Conclusions: This large study does not support the hypothesis that greater lycopene/tomato product consumption protects from prostate cancer. Evidence for protective associations in subjects with a family history of prostate cancer requires further corroboration.",
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AU - Mayne, Susan T.

AU - Peters, Ulrike

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AU - Leitzmann, Michael F.

AU - Dixon, L. Beth

AU - Urban, Donald A.

AU - Crawford, E. David

AU - Hayes, Richard B.

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N2 - Background: Dietary lycopene and tomato products may reduce risk of prostate cancer; however, uncertainty remains about this possible association. Methods: We evaluated the association between intake of lycopene and specific tomato products and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, a multicenter study designed to investigate cancer early detection methods and etiologic determinants. Participants completed both a general risk factor and a 137-item food frequency questionnaire at baseline. A total of 1,338 cases of prostate cancer were identified among 29,361 men during an average of 4.2 years of follow-up. Results: Lycopene intake was not associated with prostate cancer risk. Reduced risks were also not found for total tomato servings or for most tomato-based foods. Statistically nonsignificant inverse associations were noted for pizza [all prostate cancer: relative risk (RR), 0.83; 95% confidence interval (95% CI), 0.67-1.03 for ≥1 serving/wk versus <0.5 serving/mo; Ptrend = 0.06 and advanced prostate cancer: RR, 0.79; 95% CI, 0.56-1.10; Ptrend = 0.12] and spaghetti/tomato sauce consumption (advanced prostate cancer. RR = 0.81, 95% CI, 0.57-1.16 for ≥2 servings/wk versus <1 serving/mo; Ptrend = 0.31). Among men with a family history of prostate cancer, risks were decreased in relation to increased consumption of lycopene (Ptrend = 0.04) and specific tomato-based foods commonly eaten with fat (spaghetti, P trend = 0.12; pizza, Ptrend = 0.15; lasagna, P trend = 0.02). Conclusions: This large study does not support the hypothesis that greater lycopene/tomato product consumption protects from prostate cancer. Evidence for protective associations in subjects with a family history of prostate cancer requires further corroboration.

AB - Background: Dietary lycopene and tomato products may reduce risk of prostate cancer; however, uncertainty remains about this possible association. Methods: We evaluated the association between intake of lycopene and specific tomato products and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, a multicenter study designed to investigate cancer early detection methods and etiologic determinants. Participants completed both a general risk factor and a 137-item food frequency questionnaire at baseline. A total of 1,338 cases of prostate cancer were identified among 29,361 men during an average of 4.2 years of follow-up. Results: Lycopene intake was not associated with prostate cancer risk. Reduced risks were also not found for total tomato servings or for most tomato-based foods. Statistically nonsignificant inverse associations were noted for pizza [all prostate cancer: relative risk (RR), 0.83; 95% confidence interval (95% CI), 0.67-1.03 for ≥1 serving/wk versus <0.5 serving/mo; Ptrend = 0.06 and advanced prostate cancer: RR, 0.79; 95% CI, 0.56-1.10; Ptrend = 0.12] and spaghetti/tomato sauce consumption (advanced prostate cancer. RR = 0.81, 95% CI, 0.57-1.16 for ≥2 servings/wk versus <1 serving/mo; Ptrend = 0.31). Among men with a family history of prostate cancer, risks were decreased in relation to increased consumption of lycopene (Ptrend = 0.04) and specific tomato-based foods commonly eaten with fat (spaghetti, P trend = 0.12; pizza, Ptrend = 0.15; lasagna, P trend = 0.02). Conclusions: This large study does not support the hypothesis that greater lycopene/tomato product consumption protects from prostate cancer. Evidence for protective associations in subjects with a family history of prostate cancer requires further corroboration.

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