A prospective randomized study to determine the efficacy of steroids in treatment of croup

Bruce Leipzig, Frank A. Oski, Charles W. Cummings, James A. Stockman, Philip Swender

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated the use of dexamethasone in the management of acute laryngotracheobronchitis (croup). Thirty patients, ranging in age from eight to 60 months, were evaluated in a prospective, double-blind study. Patients received dexamethasone, 0.3 mg/kg at the time of admission and a similar dose 2 hours later, and were compared with a placebo group receiving saline. Sixteen patients received dexamethasone and 14 patients received the placebo. Severity of each group was scored by a standardized system. Patients receiving dexamethasone had a mean admission score of 8.46 points; patients receiving placebo, 8.14. Twenty-four hours after admission the patients in the treatment group had a mean score of 1.19 as contrasted with a score of 5.58 for the placebo group (P<0.01). We concluded that dexamethasone when administered in adequate dosage by an intramuscular route hastens the recovery of infants and children with acute uncomplicated croup.

Original languageEnglish (US)
Pages (from-to)194-196
Number of pages3
JournalThe Journal of pediatrics
Volume94
Issue number2
DOIs
StatePublished - Feb 1979
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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