A prospective, randomized, double-blind study for the evaluation of assisted hatching in patients with advanced maternal age

Susan E. Lanzendorf, Fariba Nehchiri, Jacob F. Mayer, Sergio Oehninger, Suheil J. Muasher

Research output: Contribution to journalArticle

Abstract

The objective of this study was to determine if assisted hatching improved the rates of implantation, clinical pregnancy and ongoing pregnancy for in-vitro fertilization (IVF) patients aged ≤ 36 years. On the day of oocyte aspiration, consenting patients were randomized according to whether all embryos underwent the hatching procedure (hatched; n = 41) or all embryos remained unhatched (controls; n = 48). Patients in both groups were treated with methylprednisolone and doxycycline starting on the day of oocyte retrieval and continuing for 4 days. The hatching procedure was performed ~ 55 h after insemination on all potential embryos for transfer and employed the release of acidified acid Tyrode's medium against the zona pellucida to create an opening ~ 20 μm in diameter. No significant differences were noted in the mean age, number of oocytes aspirated and number of embryos transferred between the hatched and control groups. In addition, no significant differences were observed in the rates of implantation (11.1 versus 11.3%), clinical pregnancy (39.0 versus 41.7%) and ongoing pregnancy (29.3 versus 35.4%) between the hatched and control groups respectively. These results suggest that assisted hatching may have no significant impact on IVF success rates in the patient population studied.

Original languageEnglish (US)
Pages (from-to)409-413
Number of pages5
JournalHuman Reproduction
Volume13
Issue number2
DOIs
StatePublished - Jan 1 1998

Keywords

  • Assisted hatching
  • Implantation
  • In-vitro fertilization
  • Zona pellucida

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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