A prospective randomised comparative study on the influence of cydosporin and azathioprine on renal auograft survival and function

F. C. Henny; A. M. Kootte; J. H. Van Bockel; W. M. Baldwin; J. Hermans; B. Bos; L. A. Van Es; L. C. Paul

doi:10.1093/oxfordjournals.ndt.a091438

A prospective randomised comparative study on the influence of cydosporin and azathioprine on renal auograft survival and function

F. C. Henny, A. M. Kootte, J. H. Van Bockel, W. M. Baldwin, J. Hermans, B. Bos, L. A. Van Es, L. C. Paul

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

To study the effectiveness and nephrotoxic sideeffects of cydosporin A (CsA) in renal transplant recipients, a prospective randomised trial was designed to compare CsA with azathioprine (Aza). Each treatment group consisted of 40 patients; in the CsA group, 18 were randomly selected for conversion to Aza after 3 months. The 1-year graft survival for CsA-treated patients was 87% compared with 66% for the Aza group (P=0.033). Anti-rejection therapy was administrated to 78% of the patients in the Aza group and 47% of those in the CsA group (P

Original language	English (US)
Pages (from-to)	44-49
Number of pages	6
Journal	Nephrology Dialysis Transplantation
Volume	1
Issue number	1
DOIs	https://doi.org/10.1093/oxfordjournals.ndt.a091438
State	Published - 1986
Externally published	Yes

Keywords

Cydosporin
Hypertension
Nephrotoxicity
Proteinuria
Renal transplantation

ASJC Scopus subject areas

Nephrology
Transplantation

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10.1093/oxfordjournals.ndt.a091438

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title = "A prospective randomised comparative study on the influence of cydosporin and azathioprine on renal auograft survival and function",

abstract = "To study the effectiveness and nephrotoxic sideeffects of cydosporin A (CsA) in renal transplant recipients, a prospective randomised trial was designed to compare CsA with azathioprine (Aza). Each treatment group consisted of 40 patients; in the CsA group, 18 were randomly selected for conversion to Aza after 3 months. The 1-year graft survival for CsA-treated patients was 87% compared with 66% for the Aza group (P=0.033). Anti-rejection therapy was administrated to 78% of the patients in the Aza group and 47% of those in the CsA group (P",

keywords = "Cydosporin, Hypertension, Nephrotoxicity, Proteinuria, Renal transplantation",

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doi = "10.1093/oxfordjournals.ndt.a091438",

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AU - Kootte, A. M.

AU - Van Bockel, J. H.

AU - Baldwin, W. M.

AU - Hermans, J.

AU - Bos, B.

AU - Van Es, L. A.

AU - Paul, L. C.

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A prospective randomised comparative study on the influence of cydosporin and azathioprine on renal auograft survival and function

Abstract

Keywords

ASJC Scopus subject areas

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