A prospective randomised comparative study on the influence of cydosporin and azathioprine on renal auograft survival and function

F. C. Henny, A. M. Kootte, J. H. Van Bockel, W. M. Baldwin, J. Hermans, B. Bos, L. A. Van Es, L. C. Paul

Research output: Contribution to journalArticle

Abstract

To study the effectiveness and nephrotoxic sideeffects of cydosporin A (CsA) in renal transplant recipients, a prospective randomised trial was designed to compare CsA with azathioprine (Aza). Each treatment group consisted of 40 patients; in the CsA group, 18 were randomly selected for conversion to Aza after 3 months. The 1-year graft survival for CsA-treated patients was 87% compared with 66% for the Aza group (P=0.033). Anti-rejection therapy was administrated to 78% of the patients in the Aza group and 47% of those in the CsA group (P

Original languageEnglish (US)
Pages (from-to)44-49
Number of pages6
JournalNephrology Dialysis Transplantation
Volume1
Issue number1
DOIs
StatePublished - 1986
Externally publishedYes

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Keywords

  • Cydosporin
  • Hypertension
  • Nephrotoxicity
  • Proteinuria
  • Renal transplantation

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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