A prospective Investigation of serum 25-hydroxyvitamin D and risk of lymphoid cancers

Unhee Lim, D. Michal Freedmam, Bruce W. HoIIis, Ronald L. Horst, Mark P. Purdue, Nilanjan Chatterjee, Stephanie J. Weinstein, Lindsay M. Morton, Arthur Schatzkin, Jarmo Virtamo, Martha S. Linet, Patricia Hartge, Demetrius Albanes

Research output: Contribution to journalArticle

Abstract

Studies indicate that higher sun exposure, especially in the recent past, is associated with reduced risk of non-Hodgkin lymphoma (NHL). Ultraviolet radiation-derived vitamin D may be protective against lymphomagenesis. We examined the relationship between prediagnostic serum 25-hydroxyvitamin D (25(OH)D) and lymphoid cancer risk in a case-control study nested within the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study cohort (1985-2002) of 29,133 Finnish male smokers (ages 50-69). We identified 270 incident lymphoid cancer cases and matched them individually with 538 controls by birth-year and month of fasting blood draw at baseline. In conditional logistic regression models for 10 nmol/L increments or tertile comparisons, serum 25(OH)D was not associated with the risk of overall lymphoid cancers, NHL (n = 208) or multiple myeloma (n = 41). Odds ratios (OR) for NHL for higher tertiles were 0.75 (95% conidence interval (CI), 0.50,1.14) and 0.82 (95% CI, 0.53,1.26). The 25(OH)D-NHL association, however, differed by follow-up duration at diagnosis. Cases diagnosed less than 7 years from the baseline showed an inverse association (OR for highest vs. lowest tertile = 0.43; 95% CI: 0.23, 0.S3; p for trend = 0.01), but not later diagnoses (OR = 1.52; 95% CI: 0.82, 2.80; p for trend = 0.17). The inverse association found for close exposure to diagnosis was not confounded by other risk factors for lymphoma or correlates of 25(OH)D. Although our findings suggest that circulating 25(OH)D is not likely associated with overall lymphoid cancer, they indicate a potentially protective effect on short-term risk of NHL.

Original languageEnglish (US)
Pages (from-to)979-986
Number of pages8
JournalInternational Journal of Cancer
Volume124
Issue number4
DOIs
StatePublished - Feb 15 2009
Externally publishedYes

Fingerprint

Non-Hodgkin's Lymphoma
Serum
Odds Ratio
Neoplasms
Logistic Models
Delayed Diagnosis
beta Carotene
alpha-Tocopherol
Solar System
Multiple Myeloma
Contraception
Vitamin D
Case-Control Studies
Fasting
Lymphoma
Cohort Studies
25-hydroxyvitamin D
Radiation

Keywords

  • 25-hydroxyvitamin D
  • Diet
  • Lymphoid neoplasms
  • Nested case-control studies
  • Non-Hodgkin lymphoma
  • Vitamin D

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Lim, U., Freedmam, D. M., HoIIis, B. W., Horst, R. L., Purdue, M. P., Chatterjee, N., ... Albanes, D. (2009). A prospective Investigation of serum 25-hydroxyvitamin D and risk of lymphoid cancers. International Journal of Cancer, 124(4), 979-986. https://doi.org/10.1002/ijc.23984

A prospective Investigation of serum 25-hydroxyvitamin D and risk of lymphoid cancers. / Lim, Unhee; Freedmam, D. Michal; HoIIis, Bruce W.; Horst, Ronald L.; Purdue, Mark P.; Chatterjee, Nilanjan; Weinstein, Stephanie J.; Morton, Lindsay M.; Schatzkin, Arthur; Virtamo, Jarmo; Linet, Martha S.; Hartge, Patricia; Albanes, Demetrius.

In: International Journal of Cancer, Vol. 124, No. 4, 15.02.2009, p. 979-986.

Research output: Contribution to journalArticle

Lim, U, Freedmam, DM, HoIIis, BW, Horst, RL, Purdue, MP, Chatterjee, N, Weinstein, SJ, Morton, LM, Schatzkin, A, Virtamo, J, Linet, MS, Hartge, P & Albanes, D 2009, 'A prospective Investigation of serum 25-hydroxyvitamin D and risk of lymphoid cancers', International Journal of Cancer, vol. 124, no. 4, pp. 979-986. https://doi.org/10.1002/ijc.23984
Lim, Unhee ; Freedmam, D. Michal ; HoIIis, Bruce W. ; Horst, Ronald L. ; Purdue, Mark P. ; Chatterjee, Nilanjan ; Weinstein, Stephanie J. ; Morton, Lindsay M. ; Schatzkin, Arthur ; Virtamo, Jarmo ; Linet, Martha S. ; Hartge, Patricia ; Albanes, Demetrius. / A prospective Investigation of serum 25-hydroxyvitamin D and risk of lymphoid cancers. In: International Journal of Cancer. 2009 ; Vol. 124, No. 4. pp. 979-986.
@article{89fb7f8e2e13455398a46b63672edddb,
title = "A prospective Investigation of serum 25-hydroxyvitamin D and risk of lymphoid cancers",
abstract = "Studies indicate that higher sun exposure, especially in the recent past, is associated with reduced risk of non-Hodgkin lymphoma (NHL). Ultraviolet radiation-derived vitamin D may be protective against lymphomagenesis. We examined the relationship between prediagnostic serum 25-hydroxyvitamin D (25(OH)D) and lymphoid cancer risk in a case-control study nested within the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study cohort (1985-2002) of 29,133 Finnish male smokers (ages 50-69). We identified 270 incident lymphoid cancer cases and matched them individually with 538 controls by birth-year and month of fasting blood draw at baseline. In conditional logistic regression models for 10 nmol/L increments or tertile comparisons, serum 25(OH)D was not associated with the risk of overall lymphoid cancers, NHL (n = 208) or multiple myeloma (n = 41). Odds ratios (OR) for NHL for higher tertiles were 0.75 (95{\%} conidence interval (CI), 0.50,1.14) and 0.82 (95{\%} CI, 0.53,1.26). The 25(OH)D-NHL association, however, differed by follow-up duration at diagnosis. Cases diagnosed less than 7 years from the baseline showed an inverse association (OR for highest vs. lowest tertile = 0.43; 95{\%} CI: 0.23, 0.S3; p for trend = 0.01), but not later diagnoses (OR = 1.52; 95{\%} CI: 0.82, 2.80; p for trend = 0.17). The inverse association found for close exposure to diagnosis was not confounded by other risk factors for lymphoma or correlates of 25(OH)D. Although our findings suggest that circulating 25(OH)D is not likely associated with overall lymphoid cancer, they indicate a potentially protective effect on short-term risk of NHL.",
keywords = "25-hydroxyvitamin D, Diet, Lymphoid neoplasms, Nested case-control studies, Non-Hodgkin lymphoma, Vitamin D",
author = "Unhee Lim and Freedmam, {D. Michal} and HoIIis, {Bruce W.} and Horst, {Ronald L.} and Purdue, {Mark P.} and Nilanjan Chatterjee and Weinstein, {Stephanie J.} and Morton, {Lindsay M.} and Arthur Schatzkin and Jarmo Virtamo and Linet, {Martha S.} and Patricia Hartge and Demetrius Albanes",
year = "2009",
month = "2",
day = "15",
doi = "10.1002/ijc.23984",
language = "English (US)",
volume = "124",
pages = "979--986",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - A prospective Investigation of serum 25-hydroxyvitamin D and risk of lymphoid cancers

AU - Lim, Unhee

AU - Freedmam, D. Michal

AU - HoIIis, Bruce W.

AU - Horst, Ronald L.

AU - Purdue, Mark P.

AU - Chatterjee, Nilanjan

AU - Weinstein, Stephanie J.

AU - Morton, Lindsay M.

AU - Schatzkin, Arthur

AU - Virtamo, Jarmo

AU - Linet, Martha S.

AU - Hartge, Patricia

AU - Albanes, Demetrius

PY - 2009/2/15

Y1 - 2009/2/15

N2 - Studies indicate that higher sun exposure, especially in the recent past, is associated with reduced risk of non-Hodgkin lymphoma (NHL). Ultraviolet radiation-derived vitamin D may be protective against lymphomagenesis. We examined the relationship between prediagnostic serum 25-hydroxyvitamin D (25(OH)D) and lymphoid cancer risk in a case-control study nested within the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study cohort (1985-2002) of 29,133 Finnish male smokers (ages 50-69). We identified 270 incident lymphoid cancer cases and matched them individually with 538 controls by birth-year and month of fasting blood draw at baseline. In conditional logistic regression models for 10 nmol/L increments or tertile comparisons, serum 25(OH)D was not associated with the risk of overall lymphoid cancers, NHL (n = 208) or multiple myeloma (n = 41). Odds ratios (OR) for NHL for higher tertiles were 0.75 (95% conidence interval (CI), 0.50,1.14) and 0.82 (95% CI, 0.53,1.26). The 25(OH)D-NHL association, however, differed by follow-up duration at diagnosis. Cases diagnosed less than 7 years from the baseline showed an inverse association (OR for highest vs. lowest tertile = 0.43; 95% CI: 0.23, 0.S3; p for trend = 0.01), but not later diagnoses (OR = 1.52; 95% CI: 0.82, 2.80; p for trend = 0.17). The inverse association found for close exposure to diagnosis was not confounded by other risk factors for lymphoma or correlates of 25(OH)D. Although our findings suggest that circulating 25(OH)D is not likely associated with overall lymphoid cancer, they indicate a potentially protective effect on short-term risk of NHL.

AB - Studies indicate that higher sun exposure, especially in the recent past, is associated with reduced risk of non-Hodgkin lymphoma (NHL). Ultraviolet radiation-derived vitamin D may be protective against lymphomagenesis. We examined the relationship between prediagnostic serum 25-hydroxyvitamin D (25(OH)D) and lymphoid cancer risk in a case-control study nested within the Alpha-Tocopherol Beta-Carotene Cancer Prevention Study cohort (1985-2002) of 29,133 Finnish male smokers (ages 50-69). We identified 270 incident lymphoid cancer cases and matched them individually with 538 controls by birth-year and month of fasting blood draw at baseline. In conditional logistic regression models for 10 nmol/L increments or tertile comparisons, serum 25(OH)D was not associated with the risk of overall lymphoid cancers, NHL (n = 208) or multiple myeloma (n = 41). Odds ratios (OR) for NHL for higher tertiles were 0.75 (95% conidence interval (CI), 0.50,1.14) and 0.82 (95% CI, 0.53,1.26). The 25(OH)D-NHL association, however, differed by follow-up duration at diagnosis. Cases diagnosed less than 7 years from the baseline showed an inverse association (OR for highest vs. lowest tertile = 0.43; 95% CI: 0.23, 0.S3; p for trend = 0.01), but not later diagnoses (OR = 1.52; 95% CI: 0.82, 2.80; p for trend = 0.17). The inverse association found for close exposure to diagnosis was not confounded by other risk factors for lymphoma or correlates of 25(OH)D. Although our findings suggest that circulating 25(OH)D is not likely associated with overall lymphoid cancer, they indicate a potentially protective effect on short-term risk of NHL.

KW - 25-hydroxyvitamin D

KW - Diet

KW - Lymphoid neoplasms

KW - Nested case-control studies

KW - Non-Hodgkin lymphoma

KW - Vitamin D

UR - http://www.scopus.com/inward/record.url?scp=58149468080&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149468080&partnerID=8YFLogxK

U2 - 10.1002/ijc.23984

DO - 10.1002/ijc.23984

M3 - Article

C2 - 19035445

AN - SCOPUS:58149468080

VL - 124

SP - 979

EP - 986

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 4

ER -