A prospective cohort study of red wine consumption and risk of prostate cancer

Siobhan Sutcliffe, Edward Giovannucci, Michael F. Leitzmann, Eric B. Rimm, Meir J. Stampfer, Walter C. Willett, Elizabeth A. Platz

Research output: Contribution to journalArticle

Abstract

In light of recent, strong inverse findings between lifetime red wine consumption and prostate cancer among younger men, we revisited our previous cohort analysis to more thoroughly investigate red wine consumption and prostate cancer in the Health Professionals Follow-up Study (HPFS). In 1986, HPFS participants reported their average consumption of red wine, white wine, beer and liquor during the past year, and their change in alcohol consumption over the prior 10 years. Prostate cancer diagnoses were ascertained on each biennial questionnaire and confirmed by medical record review. Between 1986 and 2002, 3,348 cases of prostate cancer were diagnosed among 45,433 eligible participants. Using men who did not consume red wine as the reference, no linear trend was observed between red wine consumption and prostate cancer in the full analytic cohort (p-trend = 0.57). Among men with unchanged alcohol consumption in the prior 10 years, and those additionally <65 years of age, slightly lower risks were observed for men who consumed ≤4 glasses of red wine/week, whereas null or slight increased risks were observed for men who consumed >4 glasses/week, resulting in a lack of linear trend. These findings suggest that red wine does not contribute appreciably to the etiology of prostate cancer.

Original languageEnglish (US)
Pages (from-to)1529-1535
Number of pages7
JournalInternational Journal of Cancer
Volume120
Issue number7
DOIs
StatePublished - Apr 1 2007

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Keywords

  • Alcoholic beverages
  • Cohort study
  • Prostate cancer
  • Red wine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Sutcliffe, S., Giovannucci, E., Leitzmann, M. F., Rimm, E. B., Stampfer, M. J., Willett, W. C., & Platz, E. A. (2007). A prospective cohort study of red wine consumption and risk of prostate cancer. International Journal of Cancer, 120(7), 1529-1535. https://doi.org/10.1002/ijc.22498