A proposal to facilitate weight-of-evidence assessments: Harmonization of Neurodevelopmental Environmental Epidemiology Studies (HONEES)

Eric Youngstrom, Lauren Kenworthy, Paul H. Lipkin, Michael Goodman, Katherine Squibb, Donald R. Mattison, Laura Gutermuth Anthony, Susan L. Makris, Ambuja S. Bale, Kathleen C. Raffaele, Judy S. Lakind

Research output: Contribution to journalArticle

Abstract

The ability to conduct weight-of-evidence assessments to inform the evaluation of potential environmental neurotoxicants is limited by lack of comparability of study methods, data analysis, and reporting. There is a need to establish consensus guidelines for conducting, analyzing, and reporting neurodevelopmental environmental epidemiologic studies, while recognizing that consistency is likewise needed for epidemiology studies examining other health outcomes. This paper proposes a set of considerations to be used by the scientific community at-large as a tool for systematically evaluating the quality of proposed and/or published studies in terms of their value for weight-of-evidence assessments. Particular emphasis is placed on evaluating factors influencing the risk of incorrect conclusions at the level of study findings. The proposed considerations are the first step in what must be a larger consensus-based process and can serve to catalyze such a discussion. Achieving consensus in these types of endeavors is difficult; however, opportunities exist for further interdisciplinary discussion, collaboration, and research that will help realize this goal. Broad acceptance and application of such an approach can facilitate the expanded use of environmental epidemiology studies of potential neurodevelopmental toxicants in the protection of public health, and specifically children's health.

Original languageEnglish (US)
Pages (from-to)354-359
Number of pages6
JournalNeurotoxicology and Teratology
Volume33
Issue number3
DOIs
StatePublished - May 1 2011

Keywords

  • Environmental chemicals
  • Environmental epidemiology
  • Interstudy consistency
  • Neurodevelopmental function tests
  • Risk assessment
  • Weight-of-evidence assessments

ASJC Scopus subject areas

  • Toxicology
  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

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    Youngstrom, E., Kenworthy, L., Lipkin, P. H., Goodman, M., Squibb, K., Mattison, D. R., Anthony, L. G., Makris, S. L., Bale, A. S., Raffaele, K. C., & Lakind, J. S. (2011). A proposal to facilitate weight-of-evidence assessments: Harmonization of Neurodevelopmental Environmental Epidemiology Studies (HONEES). Neurotoxicology and Teratology, 33(3), 354-359. https://doi.org/10.1016/j.ntt.2011.01.004