A promoter polymorphism of tumor necrosis factor α associated with systemic lupus erythematosus in African-Americans

Kathleen E. Sullivan, Candra Wooten, Barbara J. Schmeckpeper, Daniel Goldman, Michelle A. Petri

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. The polymorphic tumor necrosis factor α (TNFα) gene encodes a cytokine involved in inflammation, angiogenesis, and apoptosis. One polymorphic variant is associated with increased production of TNFα. This study examined the frequency of this polymorphic variant in African-American patients with systemic lupus erythematosus (SLE) compared with controls. Methods. We determined the gene frequency of the polymorphic variant of TNFα in an African-American SLE patient population and in a geographically matched African-American control population. Results. The gene frequency of the TNFα - 308A polymorphism was higher in the African-American SLE population than in the control population. This relationship was independent of major histocompatibility complex DR alleles. Conclusion. The TNFα - 308A polymorphism is associated with an increased risk of SLE in African- Americans.

Original languageEnglish (US)
Pages (from-to)2207-2211
Number of pages5
JournalArthritis and rheumatism
Volume40
Issue number12
DOIs
StatePublished - Dec 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Fingerprint

Dive into the research topics of 'A promoter polymorphism of tumor necrosis factor α associated with systemic lupus erythematosus in African-Americans'. Together they form a unique fingerprint.

Cite this